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dc.contributor.author
Pavy Le Traon, Anne
dc.contributor.author
Piedvache, A.
dc.contributor.author
Pérez Lloret, Santiago
dc.contributor.author
Calandra Buonara, G.
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Cochen De Cock, V.
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Colosimo, C.
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Cortelli, P.
dc.contributor.author
Debs, R.
dc.contributor.author
Duerr, S.
dc.contributor.author
Fanciulli, A.
dc.contributor.author
Foubert Samier, A.
dc.contributor.author
Gerdelat, Angela
dc.contributor.author
Gurevich, T.
dc.contributor.author
Krismer, F.
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Poewe, W.
dc.contributor.author
Tison, Francois
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Tranchant, C.
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Wenning, G.
dc.contributor.author
Meissner, Wassilios G.
dc.contributor.author
Rascol, Olivier
dc.date.available
2018-03-14T22:03:01Z
dc.date.issued
2015-05
dc.identifier.citation
Pavy Le Traon, Anne; Piedvache, A.; Pérez Lloret, Santiago; Calandra Buonara, G.; Cochen De Cock, V.; et al.; New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study; B M J Publishing Group; Journal Of Neurology, Neurosurgery And Psychiatry; 87; 5; 5-2015; 1-9
dc.identifier.issn
0022-3050
dc.identifier.uri
http://hdl.handle.net/11336/38852
dc.description.abstract
Objectives: Orthostatic hypotension (OH) is a key feature of multiple system atrophy (MSA), a fatal progressive neurodegenerative disorder associated with autonomic failure, parkinsonism and ataxia. This study aims (1) to determine the clinical spectrum of OH in a large European cohort of patients with MSA and (2) to investigate whether a prolonged postural challenge increases the sensitivity to detect OH in MSA. Methods: Assessment of OH during a 10 min orthostatic test in 349 patients with MSA from seven centres of the European MSA-Study Group (age: 63.6±8.8 years; disease duration: 4.2±2.6 years). Assessment of a possible relationship between OH and MSA subtype (P with predominant parkinsonism or C with predominant cerebellar ataxia), Unified MSA Rating Scale (UMSARS) scores and drug intake. Results: 187 patients (54%) had moderate (>20 mm Hg (systolic blood pressure (SBP)) and/or >10 mm Hg (diastolic blood pressure (DBP)) or severe OH (>30 mm Hg (SBP) and/or >15 mm Hg (DBP)) within 3 min and 250 patients (72%) within 10 min. OH magnitude was significantly associated with disease severity (UMSARS I, II and IV), orthostatic symptoms (UMSARS I) and supine hypertension. OH severity was not associated with MSA subtype. Drug intake did not differ according to OH magnitude except for antihypertensive drugs being less frequently, and antihypotensive drugs more frequently, prescribed in severe OH. Conclusions: This is the largest study of OH in patients with MSA. Our data suggest that the sensitivity to pick up OH increases substantially by a prolonged 10 min orthostatic challenge. These results will help to improve OH management and the design of future clinical trials.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
B M J Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Atrofia Multisistémica
dc.subject
Hipotensión Ortostática
dc.subject
Reacciones Adversas Medicamentosas
dc.subject.classification
Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
New insights into orthostatic hypotension in multiple system atrophy: a European multicentre cohort study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-13T13:59:04Z
dc.journal.volume
87
dc.journal.number
5
dc.journal.pagination
1-9
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Pavy Le Traon, Anne. University Hospital of Toulouse; Francia. Inserm; Francia
dc.description.fil
Fil: Piedvache, A.. Université Paul Sabatier; Francia
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Fil: Pérez Lloret, Santiago. University Hospital of Toulouse; Francia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
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Fil: Calandra Buonara, G.. Università di Bologna; Italia. Istituto delle Scienze Neurologiche di Bologna; Italia
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Fil: Cochen De Cock, V.. University Hospital of Toulouse; Francia. University of Montpellier; Francia
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Fil: Colosimo, C.. Sapienza Università di Roma; Italia
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Fil: Cortelli, P.. Università di Bologna; Italia. Istituto delle Scienze Neurologiche di Bologna; Italia
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Fil: Debs, R.. University Hospital of Toulouse; Francia
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Fil: Duerr, S.. Universidad de Innsbruck; Austria
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Fil: Fanciulli, A.. Universidad de Innsbruck; Austria
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Fil: Foubert Samier, A.. Centre Hospitalier Universitaire de Bordeaux; Francia. Universite de Bordeaux; Francia
dc.description.fil
Fil: Gerdelat, Angela. University Hospital of Toulouse; Francia
dc.description.fil
Fil: Gurevich, T.. Tel-Aviv University; Israel
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Fil: Krismer, F.. Universidad de Innsbruck; Austria
dc.description.fil
Fil: Poewe, W.. Universidad de Innsbruck; Austria
dc.description.fil
Fil: Tison, Francois. Universite de Bordeaux; Francia. Centre Hospitalier Universitaire de Bordeaux; Francia
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Fil: Tranchant, C.. University Hospital Hautepierre; Francia
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Fil: Wenning, G.. Universidad de Innsbruck; Austria
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Fil: Meissner, Wassilios G.. Universite de Bordeaux; Francia. Centre Hospitalier Universitaire de Bordeaux; Francia
dc.description.fil
Fil: Rascol, Olivier. University Hospital of Toulouse; Francia
dc.journal.title
Journal Of Neurology, Neurosurgery And Psychiatry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://jnnp.bmj.com/content/87/5/554
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1136/jnnp-2014-309999
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