Artículo
Brain network organization and social executive performance in frontotemporal dementia
Sedeño, Lucas ; Couto, Juan Blas Marcos
; Couto, Juan Blas Marcos ; García Cordero, Indira Ruth
; García Cordero, Indira Ruth ; Melloni, Margherita
; Melloni, Margherita ; Báez Buitrago, Sandra Jimena
; Báez Buitrago, Sandra Jimena ; Sepúlveda, Juan Pablo Morales; Fraiman Borrazás, Daniel Edmundo
; Sepúlveda, Juan Pablo Morales; Fraiman Borrazás, Daniel Edmundo ; Huepe, David; Hurtado, Esteban; Matallana, Diana; Kuljis, Rodrigo; Torralva, Teresa; Chialvo, Dante Renato
; Huepe, David; Hurtado, Esteban; Matallana, Diana; Kuljis, Rodrigo; Torralva, Teresa; Chialvo, Dante Renato ; Sigman, Mariano
; Sigman, Mariano ; Piguet, Olivier; Manes, Facundo Francisco
; Piguet, Olivier; Manes, Facundo Francisco ; Ibañez, Agustin Mariano
; Ibañez, Agustin Mariano 
 ; Couto, Juan Blas Marcos
; Couto, Juan Blas Marcos ; García Cordero, Indira Ruth
; García Cordero, Indira Ruth ; Melloni, Margherita
; Melloni, Margherita ; Báez Buitrago, Sandra Jimena
; Báez Buitrago, Sandra Jimena ; Sepúlveda, Juan Pablo Morales; Fraiman Borrazás, Daniel Edmundo
; Sepúlveda, Juan Pablo Morales; Fraiman Borrazás, Daniel Edmundo ; Huepe, David; Hurtado, Esteban; Matallana, Diana; Kuljis, Rodrigo; Torralva, Teresa; Chialvo, Dante Renato
; Huepe, David; Hurtado, Esteban; Matallana, Diana; Kuljis, Rodrigo; Torralva, Teresa; Chialvo, Dante Renato ; Sigman, Mariano
; Sigman, Mariano ; Piguet, Olivier; Manes, Facundo Francisco
; Piguet, Olivier; Manes, Facundo Francisco ; Ibañez, Agustin Mariano
; Ibañez, Agustin Mariano 
Fecha de publicación:
02/2016
Editorial:
Cambridge University Press
Revista:
Journal of the International Neuropsychological Society : Jins
ISSN:
1355-6177
Idioma:
								Inglés
							
Tipo de recurso:
							Artículo publicado
							
Clasificación temática:
Resumen
Objectives: Behavioral variant frontotemporal dementia (bvFTD) is characterized by early atrophy in the frontotemporoinsular regions. These regions overlap with networks that are engaged in social cognition-executive functions, two hallmarks deficits of bvFTD. We examine (i) whether Network Centrality (a graph theory metric that measures how important a node is in a brain network) in the frontotemporoinsular network is disrupted in bvFTD, and (ii) the level of involvement of this network in social-executive performance. Methods: Patients with probable bvFTD, healthy controls, and frontoinsular stroke patients underwent functional MRI resting-state recordings and completed social-executive behavioral measures. Results: Relative to the controls and the stroke group, the bvFTD patients presented decreased Network Centrality. In addition, this measure was associated with social cognition and executive functions. To test the specificity of these results for the Network Centrality of the frontotemporoinsular network, we assessed the main areas from six resting-state networks. No group differences or behavioral associations were found in these networks. Finally, Network Centrality and behavior distinguished bvFTD patients from the other groups with a high classification rate. Conclusions: bvFTD selectively affects Network Centrality in the frontotemporoinsular network, which is associated with high-level social and executive profile.
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
	                Citación
	                
Sedeño, Lucas; Couto, Juan Blas Marcos; García Cordero, Indira Ruth; Melloni, Margherita; Báez Buitrago, Sandra Jimena; et al.; Brain network organization and social executive performance in frontotemporal dementia; Cambridge University Press; Journal of the International Neuropsychological Society : Jins; 22; 2; 2-2016; 250-262
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