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Artículo

Brain network organization and social executive performance in frontotemporal dementia

Sedeño, LucasIcon ; Couto, Juan Blas MarcosIcon ; García Cordero, Indira RuthIcon ; Melloni, MargheritaIcon ; Báez Buitrago, Sandra JimenaIcon ; Sepúlveda, Juan Pablo Morales; Fraiman Borrazás, Daniel EdmundoIcon ; Huepe, David; Hurtado, Esteban; Matallana, Diana; Kuljis, Rodrigo; Torralva, Teresa; Chialvo, Dante RenatoIcon ; Sigman, MarianoIcon ; Piguet, Olivier; Manes, Facundo FranciscoIcon ; Ibañez, Agustin MarianoIcon
Fecha de publicación: 02/2016
Editorial: Cambridge University Press
Revista: Journal of the International Neuropsychological Society : Jins
ISSN: 1355-6177
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

Objectives: Behavioral variant frontotemporal dementia (bvFTD) is characterized by early atrophy in the frontotemporoinsular regions. These regions overlap with networks that are engaged in social cognition-executive functions, two hallmarks deficits of bvFTD. We examine (i) whether Network Centrality (a graph theory metric that measures how important a node is in a brain network) in the frontotemporoinsular network is disrupted in bvFTD, and (ii) the level of involvement of this network in social-executive performance. Methods: Patients with probable bvFTD, healthy controls, and frontoinsular stroke patients underwent functional MRI resting-state recordings and completed social-executive behavioral measures. Results: Relative to the controls and the stroke group, the bvFTD patients presented decreased Network Centrality. In addition, this measure was associated with social cognition and executive functions. To test the specificity of these results for the Network Centrality of the frontotemporoinsular network, we assessed the main areas from six resting-state networks. No group differences or behavioral associations were found in these networks. Finally, Network Centrality and behavior distinguished bvFTD patients from the other groups with a high classification rate. Conclusions: bvFTD selectively affects Network Centrality in the frontotemporoinsular network, which is associated with high-level social and executive profile.
Palabras clave: FMRI RESTING-STATE , FRONTOINSULAR STROKE , FUNCTIONAL CONNECTIVITY , GRAPH THEORY ANALYSIS , NEURODEGENERATIVE DISEASE , NODE CENTRALITY
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/38829
URL: http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1018928
DOI: http://dx.doi.org/10.1017/S1355617715000703
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Sedeño, Lucas; Couto, Juan Blas Marcos; García Cordero, Indira Ruth; Melloni, Margherita; Báez Buitrago, Sandra Jimena; et al.; Brain network organization and social executive performance in frontotemporal dementia; Cambridge University Press; Journal of the International Neuropsychological Society : Jins; 22; 2; 2-2016; 250-262
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