Mostrar el registro sencillo del ítem
dc.contributor.author
Mäki-Marttunen, Verónica
dc.contributor.author
Castro, Mariana Nair
dc.contributor.author
Olmos, Lisandro
dc.contributor.author
Leiguarda, Ramón Carlos
dc.contributor.author
Villarreal, Mirta Fabiana
dc.date.available
2018-03-14T18:03:35Z
dc.date.issued
2016-02
dc.identifier.citation
Mäki-Marttunen, Verónica; Castro, Mariana Nair; Olmos, Lisandro; Leiguarda, Ramón Carlos; Villarreal, Mirta Fabiana; Modulation of the default-mode network and the attentional network by self-referential processes in patients with disorder of consciousness; Pergamon-Elsevier Science Ltd; Neuropsychologia; 82; 2-2016; 149-160
dc.identifier.issn
0028-3932
dc.identifier.uri
http://hdl.handle.net/11336/38741
dc.description.abstract
Disorders of consciousness (DOC) are related to an altered capacity of the brain to successfully integrate and segregate information. Alterations in brain functional networks structure have been found in fMRI studies, which could account for the incapability of the brain to efficiently manage internally and externally generated information. Here we assess the modulation of neural activity in areas of the networks related to active introspective or extrospective processing in 9 patients with DOC and 17 controls using fMRI. In addition, we assess the functional connectivity between those areas in resting state. Patients were experimentally studied in an early phase after the event of brain injury (3±1 months after the event) and subsequently in a second session 4±1 months after the first session. The results showed that the concerted modulation of the default mode network (DMN) and attentional network (AN) in response to the active involvement in the task improved with the level of consciousness, reflecting an integral recovery of the brain in its ability to be engaged in cognitive processes. In addition, functional connectivity decreased between the DMN and AN with recovery. Our results help to further understand the neural underpins of the disorders of consciousness.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Attentional Network
dc.subject
Consciousness Disorders
dc.subject
Default Mode Network
dc.subject
Functional Connectivity
dc.subject
Functional Magnetic Resonance Imaging
dc.subject
Self-Reflection
dc.title
Modulation of the default-mode network and the attentional network by self-referential processes in patients with disorder of consciousness
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-14T17:06:16Z
dc.journal.volume
82
dc.journal.pagination
149-160
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Mäki-Marttunen, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Castro, Mariana Nair. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Olmos, Lisandro. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Leiguarda, Ramón Carlos. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
dc.description.fil
Fil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
dc.journal.title
Neuropsychologia
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0028393216300215
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuropsychologia.2016.01.022
Archivos asociados