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dc.contributor.author
Ciapponi, Agustín
dc.contributor.author
Lee, Alison
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Bardach, Ariel Esteban
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Glujovsky, Demián
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Rey Ares, Lucila
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Luisa Cafferata, María
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Valanzasca, Pilar
dc.contributor.author
García Martí, Sebastián
dc.date.available
2018-03-13T20:54:10Z
dc.date.issued
2016-12
dc.identifier.citation
Ciapponi, Agustín; Lee, Alison; Bardach, Ariel Esteban; Glujovsky, Demián; Rey Ares, Lucila; et al.; Interchangeability between Pneumococcal Conjugate Vaccines: A Systematic Review and Meta-Analysis; Elsevier Inc; Value in Health Regional Issues; 11; 12-2016; 24-34
dc.identifier.issn
2212-1102
dc.identifier.uri
http://hdl.handle.net/11336/38713
dc.description.abstract
Objectives: To assess the efficacy, cost-effectiveness, immunogenicity, and safety related to the interchangeability between pneumococcal conjugate vaccines (PCVs) and vaccination schedules in pediatric population. Methods: Systematic searches were conducted in December 2010 and April 2015 for economic evaluations in MEDLINE, EMBASE, LILACS, and Cochrane Central Register of Controlled Trials. Web sites and databases from medical societies, experts, and associations related to the topic, proceedings or congressional annals, and doctoral theses were also searched. No language or temporal restriction was applied. We included randomized controlled trials, economic evaluations, and systematic reviews evaluating antibody response, cost-effectiveness, and effectiveness of PCVs' interchangeability. A Strengthening the Reporting of Observational Studies in Epidemiology-based checklist was used to assess the risk of bias in observational studies and a Cochrane approach for experimental/quasi-experimental studies. Pairs of reviewers independently selected (through the Web-based Early Reviewer Organizer Software), assessed the quality, and extracted the data of the studies. Discrepancies were resolved by consensus. We planned to perform meta-analysis whenever appropriate. Results: Forty-six of 202 studies were included. There was no direct information available on the interchangeability between PCVs. The immunogenicity and safety between the 10-valent PCV (PCV10) and the 7-valent PCV were similar when both vaccines were coadministered with other routine pediatric vaccines. PCV10 and 13-valent PCV (PCV13) were consistently more cost-effective than 7-valent PCV. Conclusions: There was no direct comparative information available on the interchangeability among PCVs, but they have pretty similar immunogenicity and safety. PCV10 versus PCV13 cost-effectiveness varied according to price, indirect effects, and indirect costs. PCV10 gains more quality-adjusted life-years because of the prevention of more frequent yet less severe events such as otitis media, and PCV13 prevents less frequent but more costly events such as invasive diseases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Conjugated Pneumococcal Vaccine
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Cost-Effectiveness
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Efficacy
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Immunogenicity
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Interchangeability
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Safety
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Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Interchangeability between Pneumococcal Conjugate Vaccines: A Systematic Review and Meta-Analysis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-12T14:23:32Z
dc.journal.volume
11
dc.journal.pagination
24-34
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Ciapponi, Agustín. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lee, Alison. Instituto de Efectividad Clínica y Sanitaria; Argentina. Centro de Excelencia en Salud Cardiovascular para América del Sur; Argentina
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Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.description.fil
Fil: Glujovsky, Demián. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.description.fil
Fil: Rey Ares, Lucila. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.description.fil
Fil: Luisa Cafferata, María. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.description.fil
Fil: Valanzasca, Pilar. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.description.fil
Fil: García Martí, Sebastián. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Value in Health Regional Issues
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.vhri.2015.12.001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2212109916000029
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