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dc.contributor.author
Giubergia, Verónica  
dc.contributor.author
Castaños, Claudio  
dc.contributor.author
Gravina, Luis  
dc.contributor.author
Chertkoff, Lilien Patricia  
dc.date.available
2016-01-28T19:57:21Z  
dc.date.issued
2013-03  
dc.identifier.citation
Giubergia, Verónica; Castaños, Claudio; Gravina, Luis; Chertkoff, Lilien Patricia; Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol; Elsevier; Annals of Allergy, Asthama & Immunology; 110; 3; 3-2013; 156-160  
dc.identifier.issn
1081-1206  
dc.identifier.uri
http://hdl.handle.net/11336/3865  
dc.description.abstract
Background: New evidence suggests that different β2-adrenergic receptor (β2AR) polymorphisms may influence asthma control in patients receiving long-acting β2-agonists (LABAs) as regular therapy. Objectives: To determine the influence of β2AR polymorphisms on asthma exacerbations in children with severe asthma from Argentina receiving inhaled corticosteroid (ICS) and LABAs regularly. Methods: Ninety-seven children with severe asthma were genotyped for polymorphisms of β2AR at codons 16 and 27. The number of severe exacerbations, the time of first asthma exacerbation, and the number of hospitalizations during 12 months were assessed. Changes on pulmonary function from the beginning to the end of the study were also evaluated. Results: The number of overall asthma exacerbations and the proportion of children with these events were similar among β2AR genotypes at position 16 (Arg/Arg, Arg/Gly, and Gly/Gly) and at position 27 (Gln/Gln, Gln/Glu, and Glu/Glu). The time to first asthma exacerbation was similar among individuals carrying different β2AR polymorphisms. No β2AR genotype association was found in relation to the number of hospitalizations. Longitudinal analysis of forced expiratory volume in 1 second from baseline to the end of the study also showed no differences among β2AR genotypes at position 16 or 27. No association was observed among the 3 most common haplotypes (Arg/Arg-Gln/Gln, Gly/Gly-Gln/Gln, and Gly/Gly-Glu/Glu) and the number of participants with asthmatic crisis or with the overall number of exacerbations. Conclusion: β2AR polymorphisms were not associated with an increased risk of having asthma exacerbations or lung function decline in a population of Argentinian children with severe asthma receiving ICS and LABAs regularly.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
B2-Adrenergic  
dc.subject
Salmeterol  
dc.subject
Asthma  
dc.subject.classification
Genética Humana  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-03-30 10:35:44.97925-03  
dc.journal.volume
110  
dc.journal.number
3  
dc.journal.pagination
156-160  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Giubergia, Verónica. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina  
dc.description.fil
Fil: Castaños, Claudio. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina  
dc.description.fil
Fil: Gravina, Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina  
dc.description.fil
Fil: Chertkoff, Lilien Patricia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Annals of Allergy, Asthama & Immunology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1081120612010332  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1016/j.anai.2012.12.018  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/1081-1206