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dc.contributor.author
Giubergia, Verónica
dc.contributor.author
Castaños, Claudio
dc.contributor.author
Gravina, Luis
dc.contributor.author
Chertkoff, Lilien Patricia
dc.date.available
2016-01-28T19:57:21Z
dc.date.issued
2013-03
dc.identifier.citation
Giubergia, Verónica; Castaños, Claudio; Gravina, Luis; Chertkoff, Lilien Patricia; Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol; Elsevier; Annals of Allergy, Asthama & Immunology; 110; 3; 3-2013; 156-160
dc.identifier.issn
1081-1206
dc.identifier.uri
http://hdl.handle.net/11336/3865
dc.description.abstract
Background: New evidence suggests that different β2-adrenergic receptor (β2AR) polymorphisms may influence asthma control in patients receiving long-acting β2-agonists (LABAs) as regular therapy.
Objectives: To determine the influence of β2AR polymorphisms on asthma exacerbations in children with severe asthma from Argentina receiving inhaled corticosteroid (ICS) and LABAs regularly.
Methods: Ninety-seven children with severe asthma were genotyped for polymorphisms of β2AR at codons 16 and 27. The number of severe exacerbations, the time of first asthma exacerbation, and the number of hospitalizations during 12 months were assessed. Changes on pulmonary function from the beginning to the end of the study were also evaluated.
Results: The number of overall asthma exacerbations and the proportion of children with these events were similar among β2AR genotypes at position 16 (Arg/Arg, Arg/Gly, and Gly/Gly) and at position 27 (Gln/Gln, Gln/Glu, and Glu/Glu). The time to first asthma exacerbation was similar among individuals carrying different β2AR polymorphisms. No β2AR genotype association was found in relation to the number of hospitalizations. Longitudinal analysis of forced expiratory volume in 1 second from baseline to the end of the study also showed no differences among β2AR genotypes at position 16 or 27. No association was observed among the 3 most common haplotypes (Arg/Arg-Gln/Gln, Gly/Gly-Gln/Gln, and Gly/Gly-Glu/Glu) and the number of participants with asthmatic crisis or with the overall number of exacerbations.
Conclusion: β2AR polymorphisms were not associated with an increased risk of having asthma exacerbations or lung function decline in a population of Argentinian children with severe asthma receiving ICS and LABAs regularly.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
B2-Adrenergic
dc.subject
Salmeterol
dc.subject
Asthma
dc.subject.classification
Genética Humana
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
110
dc.journal.number
3
dc.journal.pagination
156-160
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Giubergia, Verónica. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.description.fil
Fil: Castaños, Claudio. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.description.fil
Fil: Gravina, Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.description.fil
Fil: Chertkoff, Lilien Patricia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Annals of Allergy, Asthama & Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1081120612010332
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1016/j.anai.2012.12.018
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/1081-1206
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