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dc.contributor.author
Fridman, Osvaldo
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dc.contributor.author
Gariglio Zappellini, Luis Osvaldo
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dc.contributor.author
Riviere, Stephanie
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dc.contributor.author
Porcile, Rafael
dc.contributor.author
Fuchs, Alicia Graciela
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dc.contributor.author
Potenzoni, Miguel
dc.date.available
2018-03-12T21:51:04Z
dc.date.issued
2016-10
dc.identifier.citation
Fridman, Osvaldo; Gariglio Zappellini, Luis Osvaldo; Riviere, Stephanie; Porcile, Rafael; Fuchs, Alicia Graciela; et al.; Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia; Elsevier; Archivos de Cardiología de México; 86; 4; 10-2016; 350-357
dc.identifier.issn
1405-9940
dc.identifier.uri
http://hdl.handle.net/11336/38651
dc.description.abstract
Objectives: Oxidative stress and inflammation are important processes in development of atherosclerosis. Paraoxonase 1 (PON1) is a bioscavenger enzyme associated with inflammation and oxidative stress. We evaluate the association of two single nucleotide polymorphisms in PON1 gene, and enzyme activities with lipid profile and glycemia. Methods: This case-control study consisted of 126 patients with coronary artery disease (CAD) and 203 healthy controls. PON Q192R and L55M polymorphisms were detected by real-time PCR. Paraoxonase and arylesterase activities were determined spectrophotometrically. Blood glucose, cholesterol, triglycerides, HDL, and LDL were measured. Results: PON1 QR192 polymorphism had a major effect on paraoxonase but no effect on arylesterase serum activities. Paraoxonase activity was higher in RR genotype and lowest in QQ genotype. Paraoxonase and arylesterase activities were higher in LL and lower in MM genotypes of PON1 LM55 polymorphism. RQ and LM variants showed intermediate activities between respective homozygous. Elevated concentrations of triglycerides in cases correlate with QQ variant or the presence of M allele. Glucose levels were elevated in cases with QQ variant or with the presence of M allele. Cholesterol and LDL did not show variations in control and cases with any variant of both polymorphisms. HDL is lower in cases with respect to controls independently of genotypes. All differences were significant with p < 0.05.
dc.format
application/pdf
dc.language.iso
spa
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Argentina
dc.subject
Coronary Artery Disease
dc.subject
Enzymatic Activities
dc.subject
Genetic Polymorphisms
dc.subject
Glycemia
dc.subject
Lipid Profile
dc.subject
Paraoxonase
dc.subject.classification
Salud Ocupacional
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia
dc.title
Polimorfismos en el gen de la paraoxonasa 1 y sus actividades enzimáticas en la enfermedad coronaria. Su relación con el perfil lipídico y la glucemia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-12T19:28:57Z
dc.journal.volume
86
dc.journal.number
4
dc.journal.pagination
350-357
dc.journal.pais
México
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dc.description.fil
Fil: Fridman, Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Abierta Interamericana; Argentina
dc.description.fil
Fil: Gariglio Zappellini, Luis Osvaldo. Universidad Abierta Interamericana; Argentina
dc.description.fil
Fil: Riviere, Stephanie. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Abierta Interamericana; Argentina
dc.description.fil
Fil: Porcile, Rafael. Universidad Abierta Interamericana; Argentina
dc.description.fil
Fil: Fuchs, Alicia Graciela. Universidad Abierta Interamericana; Argentina
dc.description.fil
Fil: Potenzoni, Miguel. Universidad Abierta Interamericana; Argentina
dc.journal.title
Archivos de Cardiología de México
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.acmx.2016.08.001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.elsevier.es/es-revista-archivos-cardiologia-mexico-293-linkresolver-paraoxonase-1-gene-polymorphisms-enzyme-S1405994016300751
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