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Artículo

Human Umbilical Cord Perivascular Cells Exhibited Enhanced Migration Capacity towards Hepatocellular Carcinoma in Comparison with Bone Marrow Mesenchymal Stromal Cells: A Role for Autocrine Motility Factor Receptor

Bayo Fina, Juan MiguelIcon ; Fiore, Esteban JuanIcon ; Aquino, Jorge BenjaminIcon ; Malvicini, MarianaIcon ; Rizzo, Manglio MiguelIcon ; Peixoto, EstanislaoIcon ; Alaniz, Laura DanielaIcon ; Piccioni, Flavia ValeriaIcon ; Bolontrade, Marcela FabianaIcon ; Podhajcer, Osvaldo LuisIcon ; García, Mariana GabrielaIcon ; Mazzolini Rizzo, Guillermo DanielIcon
Fecha de publicación: 07/2014
Editorial: Hindawi Publishing Corporation
Revista: BioMed Research International
ISSN: 2314-6133
e-ISSN: 2314-6141
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Hepatocellular carcinoma (HCC) is the third cause of cancer-related death worldwide. Unfortunately, the incidence and mortality associated with HCC are increasing. Therefore, new therapeutic strategies are urgently needed and the use of mesenchymal stromal cells (MSCs) as carrier of therapeutic genes is emerging as a promising option. Different sources of MSCs are being studied for cell therapy and bone marrow-derived cells are the most extensively explored; however, birth associated-tissues represent a very promising source. The aim of this work was to compare the in vitro and in vivo migration capacity between bone marrow MSCs (BM-MSCs) and human umbilical cord perivascular cells (HUCPVCs) towards HCC. We observed that HUCPVCs presented higher in vitro and in vivo migration towards factors released by HCC. The expression of autocrine motility factor (AMF) receptor, genes related with the availability of the receptor on the cell surface (caveolin-1 and -2) and metalloproteinase 3, induced by the receptor activation and important for cell migration, was increased in HUCPVCs. The chemotactic response towards recombinant AMF was increased in HUCPVCs compared to BM-MSCs, and its inhibition in the conditioned medium from HCC induced higher decrease in HUCPVC migration than in BM-MSC. Our results indicate that HUCPVCs could be a useful cellular source to deliver therapeutic genes to HCC.
Palabras clave: Human Umbilical Cord Perivascular Cells , Mesenchymal Stromal Cells , Hcc , Autocrine Motility Factor Receptor , Migration
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/38553
URL: https://www.hindawi.com/journals/bmri/2014/837420/
DOI: http://dx.doi.org/10.1155/2014/837420
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Bayo Fina, Juan Miguel; Fiore, Esteban Juan; Aquino, Jorge Benjamin; Malvicini, Mariana; Rizzo, Manglio Miguel; et al.; Human Umbilical Cord Perivascular Cells Exhibited Enhanced Migration Capacity towards Hepatocellular Carcinoma in Comparison with Bone Marrow Mesenchymal Stromal Cells: A Role for Autocrine Motility Factor Receptor; Hindawi Publishing Corporation; BioMed Research International; 2014; 7-2014
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