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dc.contributor.author
Fundia, Ariela Freya
dc.contributor.author
Weich, Natalia
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Crivelli, Adriana
dc.contributor.author
La Motta, Graciela
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Larripa, Irene Beatriz
dc.contributor.author
Slavutsky, Irma Rosa
dc.date.available
2018-03-09T21:04:55Z
dc.date.issued
2014-01
dc.identifier.citation
Fundia, Ariela Freya; Weich, Natalia; Crivelli, Adriana; La Motta, Graciela; Larripa, Irene Beatriz; et al.; Glutathione S-transferase gene polymorphisms in celiac disease and their correlation with genomic instability phenotype; Elsevier Masson; Clinics and Research in Hepatology and Gastroenterology; 38; 3; 1-2014; 379-384
dc.identifier.issn
2210-741X
dc.identifier.uri
http://hdl.handle.net/11336/38500
dc.description.abstract
Background and objective: Genomic instability and reduced glutathione S-transferase (GST) activity have been identified as potential risk factors for malignant complications in celiac disease (CD). In this study, we assessed the possible influence of GST polymorphisms on genome instability phenotypes in a genetically characterised group of celiac patients from previous studies. Methods: The deletion polymorphisms in GSTM1 and GSTT1 genes and the single-nucleotide polymorphism GSTP1 c.313A>G were genotyped using PCR in a set of 20 untreated adult patients with a known genomic instability phenotype and 69 age- and sex-matched healthy individuals. Results: The frequencies of variant genotypes in patients were GSTM1-null (30%), GSTT1-null (5%), GSTP1-AG (60%) and GSTP1-GG (15%), and they showed no differences from controls. No significant differences were found in the genotype distribution based on telomere length. Cases with GSTM1-null genotype (83%) and microsatellite stability were more frequent than those with genomic instability. Moreover, carriers of GSTP1-variant genotype (73%) and stable phenotype were significantly increased compared to unstable patients (27%) (P=0.031). No differences were found according to the clinical-pathological characteristics of celiac cases. Conclusions: No association between GST polymorphic variants and celiac-associated genomic instability was proven in our cohort. Future studies should explore the usefulness of other biomarkers to distinguish celiac patients who are susceptible to cancer development.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Masson
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Glutathione S- Transferase
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Genetics Polymorphisms
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Celiac Disease
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Genomic Instability
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Otras Ciencias Biológicas
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Glutathione S-transferase gene polymorphisms in celiac disease and their correlation with genomic instability phenotype
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-09T18:59:58Z
dc.journal.volume
38
dc.journal.number
3
dc.journal.pagination
379-384
dc.journal.pais
Francia
dc.journal.ciudad
Paris
dc.description.fil
Fil: Fundia, Ariela Freya. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Weich, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Crivelli, Adriana. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martin; Argentina
dc.description.fil
Fil: La Motta, Graciela. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martin; Argentina
dc.description.fil
Fil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
Clinics and Research in Hepatology and Gastroenterology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.clinre.2014.01.007
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2210740114000151
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