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Artículo

Cognitive reserve and AβI-42 in mild cognitive impairment (Argentina-Alzheimer’s disease neuroimaging initiative)

Harris, PaulaIcon ; Suarez, Marcos Fernandez; Surace, Ezequiel IgnacioIcon ; Chrem Mendez, Patricio Alexis; Martín, María Eugenia; Clarens, María Florencia; Tapajoz Pereira de Sampaio, FernandaIcon ; Russo, María Julieta; Campos, Jorge; Guinjoan, Salvador MartínIcon ; Sevlever, Gustavo; Allegri, Ricardo FranciscoIcon
Fecha de publicación: 10/2015
Editorial: Dove Press
Revista: Neuropsychiatric Disease and Treatment
ISSN: 1176-6328
e-ISSN: 1178-2021
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Medicina Critica y de Emergencia

Resumen

Background: The purpose of this study was to investigate the relationship between cognitive reserve and concentration of Aβ1-42 in the cerebrospinal fluid (CSF) of patients with mild cognitive impairment, those with Alzheimer’s disease, and in control subjects. Methods: Thirty-three participants from the Argentina-Alzheimer’s Disease Neuroimaging Initiative database completed a cognitive battery, the Cognitive Reserve Questionnaire (CRQ), and an Argentinian accentuation reading test (TAP-BA) as a measure of premorbid intelligence, and underwent lumbar puncture for CSF biomarker quantification. Results: The CRQ significantly correlated with TAP-BA, education, and Aβ1-42. When considering Aβ1-42 levels, significant differences were found in CRQ scores; higher levels of CSF Aβ1-42 were associated with higher CRQ scores. Conclusion: Reduced Aβ1-42 in CSF is considered as evidence of amyloid deposition in the brain. Previous results suggest that individuals with higher education, higher occupational attainment, and participation in leisure activities (cognitive reserve) have a reduced risk of developing Alzheimer’s disease. Our results support the notion that enhanced neural activity has a protective role in mild cognitive impairment, as evidenced by higher CSF Aβ1-42 levels in individuals with more cognitive reserve.
Palabras clave: Alzheimer'S Disease , Amyloid , Biomarkers , Cerebrospinal Fluid
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial 2.5 Unported (CC BY-NC 2.5)
Identificadores
URI: http://hdl.handle.net/11336/38492
DOI: http://dx.doi.org/10.2147/NDT.S84292
URL: https://www.dovepress.com/cognitive-reserve-and-abeta1-42-in-mild-cognitive-impa
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605252/
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Citación
Harris, Paula; Suarez, Marcos Fernandez; Surace, Ezequiel Ignacio; Chrem Mendez, Patricio Alexis; Martín, María Eugenia; et al.; Cognitive reserve and AβI-42 in mild cognitive impairment (Argentina-Alzheimer’s disease neuroimaging initiative); Dove Press; Neuropsychiatric Disease and Treatment; 11; 10-2015; 2599-2604
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