Artículo

Long-Term Follow-up of STAT5B Deficiency in Three Argentinian Patients: Clinical and Immunological Features

Bezrodnik, LilianaIcon ; Di Giovanni, Daniela; Caldirola, María Soledad; Esnaola Azcoiti, María; Torgerson, Troy; Gaillard, María Isabel
Fecha de publicación: 03/2015
Editorial: Springer/Plenum Publishers
Revista: Journal of Clinical Immunology
ISSN: 0271-9142
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The signal transducer and activator of transcription (STAT) family of proteins regulate gene transcription in response to a variety of cytokines. STAT5B, in particular, plays an important role in T cells, where it is a key mediator of interleukin-2 (IL-2) induced responses. STAT5B deficiency causes a rare autosomal recessive disorder reported in only a handful of individuals. There are currently ten published cases of STAT5B deficiency, four of which are Argentinians.
Palabras clave: Dysregulatory Syndrome , Growth Hormone , Lymphocytic Interstitial Pneumonitis , Primary Immunodeficiency , Regulatory T Cells , Stat5b
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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URI: http://hdl.handle.net/11336/38427
URL: https://link.springer.com/article/10.1007%2Fs10875-015-0145-5
DOI: http://dx.doi.org/10.1007/s10875-015-0145-5
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Citación
Bezrodnik, Liliana; Di Giovanni, Daniela; Caldirola, María Soledad; Esnaola Azcoiti, María; Torgerson, Troy; et al.; Long-Term Follow-up of STAT5B Deficiency in Three Argentinian Patients: Clinical and Immunological Features; Springer/Plenum Publishers; Journal of Clinical Immunology; 35; 3; 3-2015; 264-272
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