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dc.contributor.author
Baneth, Gad  
dc.contributor.author
Jacobsen, Monica Ofelia  
dc.contributor.author
Cardoso, Luís  
dc.contributor.author
Schnittger, Leonhard  
dc.date.available
2018-03-09T17:43:01Z  
dc.date.issued
2015-04  
dc.identifier.citation
Baneth, Gad; Jacobsen, Monica Ofelia; Cardoso, Luís; Schnittger, Leonhard; Reclassification of Theileria annae as Babesia vulpes sp. nov.; BioMed Central; Parasites and Vectors; 8; 1; 4-2015; 1-7  
dc.identifier.issn
1756-3305  
dc.identifier.uri
http://hdl.handle.net/11336/38412  
dc.description.abstract
Background: Theileria annae is a tick-transmitted small piroplasmid that infects dogs and foxes in North America and Europe. Due to disagreement on its placement in the Theileria or Babesia genera, several synonyms have been used for this parasite, including Babesia Spanish dog isolate, Babesia microti-like, Babesia (Theileria) annae, and Babesia cf. microti. Infections by this parasite cause anemia, thrombocytopenia, and azotemia in dogs but are mostly subclinical in red foxes (Vulpes vulpes). Furthermore, high infection rates have been detected among red fox populations in distant regions strongly suggesting that these canines act as the parasite's natural host. This study aims to reassess and harmonize the phylogenetic placement and binomen of T. annae within the order Piroplasmida. Methods: Four molecular phylogenetic trees were constructed using a maximum likelihood algorithm based on DNA alignments of: (i) near-complete 18S rRNA gene sequences (n∈=∈76 and n∈=∈93), (ii) near-complete and incomplete 18S rRNA gene sequences (n∈=∈92), and (iii) tubulin-beta gene sequences (n∈=∈32) from B. microti and B. microti-related parasites including those detected in dogs and foxes. Results: All phylogenetic trees demonstrate that T. annae and its synonyms are not Theileria parasites but are most closely related with B. microti. The phylogenetic tree based on the 18S rRNA gene forms two separate branches with high bootstrap value, of which one branch corresponds to Babesia species infecting rodents, humans, and macaques, while the other corresponds to species exclusively infecting carnivores. Within the carnivore group, T. annae and its synonyms from distant regions segregate into a single clade with a highly significant bootstrap value corroborating their separate species identity. Conclusion: Phylogenetic analysis clearly shows that T. annae and its synonyms do not pertain to Theileria and can be clearly defined as a separate species. Based on the facts that T. annae and its synonyms have not been shown to have a leukocyte stage, as expected in Theileria, do not infect humans and rodents as B. microti, and cluster phylogenetically as a separate species, this study proposes to name this parasite Babesia vulpes sp. nov., after its natural host, the red fox V. vulpes.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
BioMed Central  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Babesia (Theileria) Annae  
dc.subject
Babesia Annae  
dc.subject
Babesia Cf. Microti  
dc.subject
Babesia Microti  
dc.subject
Babesia Microti-Like  
dc.subject
Babesia Spanish Dog Isolate  
dc.subject
Babesia Vulpes  
dc.subject
Dog  
dc.subject
Red Fox  
dc.subject
Theileria Annae  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Reclassification of Theileria annae as Babesia vulpes sp. nov.  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-09T14:45:14Z  
dc.journal.volume
8  
dc.journal.number
1  
dc.journal.pagination
1-7  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Baneth, Gad. The Hebrew University of Jerusalem; Israel  
dc.description.fil
Fil: Jacobsen, Monica Ofelia. Instituto Nacional de Tecnología Agropecuaria. Centro Nacional de Investigaciones Agropecuarias Castelar. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Cardoso, Luís. Universidade de Trás-os-Montes e Alto Douro; Portugal  
dc.description.fil
Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria. Centro Nacional de Investigaciones Agropecuarias Castelar. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Parasites and Vectors  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s13071-015-0830-5  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-015-0830-5