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dc.contributor.author
Farías, Rubén Oscar
dc.contributor.author
Bortolussi, Silva
dc.contributor.author
Bonvicini Menéndez, Pablo Federico
dc.contributor.author
González, Sara Josefina
dc.date.available
2018-03-09T15:39:43Z
dc.date.issued
2014-12
dc.identifier.citation
Farías, Rubén Oscar; Bortolussi, Silva; Bonvicini Menéndez, Pablo Federico; González, Sara Josefina; Exploring Boron Neutron Capture Therapy for non-small cell lung cancer; Istituti Editoriali e Poligrafici Internazionali; Physica Medica; 30; 8; 12-2014; 888-897
dc.identifier.issn
1120-1797
dc.identifier.uri
http://hdl.handle.net/11336/38401
dc.description.abstract
Boron Neutron Capture Therapy (BNCT) is a radiotherapy that combines biological targeting and high LET radiation. It consists in the enrichment of tumour with 10B and in the successive irradiation of the target with low energy neutrons producing charged particles that mainly cause non-repairable damages to the cells.The feasibility to treat Non Small Cells Lung Cancer (NSCLC) with BNCT was explored. This paper proposes a new approach to determine treatment plans, introducing the possibility to choose the irradiation start and duration to maximize the tumour dose. A Tumour Control Probability (TCP) suited for lung BNCT as well as other high dose radiotherapy schemes was also introduced.Treatment plans were evaluated in localized and disseminated lung tumours. Semi-ideal and real energy spectra beams were employed to assess the best energy range and the performance of non-tailored neutron sources for lung tumour treatments.The optimal neutron energy is within [500eV-3keV], lower than the 10keV suggested for the treatment of deep-seated tumours in the brain. TCPs higher than 0.6 and up to 0.95 are obtained for all cases.Conclusions drawn from [Suzuki etal., Int Canc Conf J 1 (4) (2012) 235-238] supporting the feasibility of BNCT for shallow lung tumours are confirmed, however discussions favouring the treatment of deeper lesions and disseminated disease are also opened. Since BNCT gives the possibility to deliver a safe and potentially effective treatment for NSCLC, it can be considered a suitable alternative for patients with few or no treatment options.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Istituti Editoriali e Poligrafici Internazionali
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bnct
dc.subject
Lung Tumours
dc.subject
Mcnp
dc.subject
Tumour Control Probability
dc.subject.classification
Otras Ciencias Físicas
dc.subject.classification
Ciencias Físicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.subject.classification
Otras Ciencias de la Salud
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Exploring Boron Neutron Capture Therapy for non-small cell lung cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-02-26T15:09:55Z
dc.journal.volume
30
dc.journal.number
8
dc.journal.pagination
888-897
dc.journal.pais
Italia
dc.description.fil
Fil: Farías, Rubén Oscar. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones No Nucleares. Gerencia Física (Centro Atómico Constituyentes). Proyecto Tandar; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Bortolussi, Silva. Università degli Studi di Pavia; Italia
dc.description.fil
Fil: Bonvicini Menéndez, Pablo Federico. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina
dc.description.fil
Fil: González, Sara Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones No Nucleares. Gerencia Física (Centro Atómico Constituyentes). Proyecto Tandar; Argentina
dc.journal.title
Physica Medica
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1120179714005067
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ejmp.2014.07.342
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