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Artículo

Disrupting the wall accumulation of human sperm cells by artificial corrugation

Guidobaldi, Héctor AlejandroIcon ; Jeyaram, Y.; Condat, CarlosIcon ; Oviedo Diego, Mariela AnahíIcon ; Berdakin, IvanIcon ; Moshchalkov, V. V.; Giojalas, Laura CeciliaIcon ; Silhanek, A. V.; Marconi, Veronica IrisIcon
Fecha de publicación: 04/2015
Editorial: American Institute of Physics
Revista: Biomicrofluidics
ISSN: 1932-1058
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas; Otras Biotecnologías de la Salud

Resumen

Many self-propelled microorganisms are attracted to surfaces. This makes their dynamics in restricted geometries very different from that observed in the bulk. Swimming along walls is beneficial for directing and sorting cells, but may be detrimental if homogeneous populations are desired, such as in counting microchambers. In this work, we characterize the motion of human sperm cells ~60 lm long, strongly confined to ~25 lm shallow chambers. We investigate the nature of the cell trajectories between the confining surfaces and their accumulation near the borders. Observed cell trajectories are composed of a succession of quasi-circular and quasi-linear segments. This suggests that the cells follow a path of intermittent trappings near the top and bottom surfaces separated by stretches of quasi-free motion in between the two surfaces, as confirmed by depth resolved confocal microscopy studies. We show that the introduction of artificial petal-shaped corrugation in the lateral boundaries removes the tendency of cells to accumulate near the borders, an effect which we hypothesize may be valuable for microfluidic applications in biomedicine.
Palabras clave: Human Sperm , Motility , Microdevices , Strong Confinement , Fertility , Cell Dynamics
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/38323
DOI: http://dx.doi.org/10.1063/1.4918979
URL: https://aip.scitation.org/doi/10.1063/1.4918979
Colecciones
Articulos(IFEG)
Articulos de INST.DE FISICA ENRIQUE GAVIOLA
Articulos(IIBYT)
Articulos de INSTITUTO DE INVESTIGACIONES BIOLOGICAS Y TECNOLOGICAS
Citación
Guidobaldi, Héctor Alejandro; Jeyaram, Y.; Condat, Carlos; Oviedo Diego, Mariela Anahí; Berdakin, Ivan; et al.; Disrupting the wall accumulation of human sperm cells by artificial corrugation; American Institute of Physics; Biomicrofluidics; 9; 2; 4-2015; 1-10; 024122
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