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dc.contributor.author
Periolo, Natalia
dc.contributor.author
Avaro, M.
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Czech, A.
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Russo, M.
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Benedetti, E.
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Pontoriero, A.
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Campos, A.
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Martinez Peralta, Liliana A.
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Baumeister, Elsa
dc.date.available
2018-03-08T19:46:32Z
dc.date.issued
2015-03
dc.identifier.citation
Periolo, Natalia; Avaro, M.; Czech, A.; Russo, M.; Benedetti, E.; et al.; Pregnant women infected with pandemic influenza A(H1N1)pdm09 virus showed differential immune response correlated with disease severity; Elsevier Science; Journal of Clinical Virology; 64; 3-2015; 52-58
dc.identifier.issn
1386-6532
dc.identifier.uri
http://hdl.handle.net/11336/38309
dc.description.abstract
Background: During pregnancy, immunological and hormonal alterations place women at increased risk for influenza-related severe illnesses including hospitalization and death. Although A(H1N1) pdm09 infection resulted in increased disease severity in pregnant women, the precise mechanisms responsible for this risk have yet to be established. Objectives: The present study was aimed to investigate the role of host chemokines and cytokine profiles in A(H1N1) pdm09 infection regarding disease severity in pregnant women. Study design: This retrospective survey examined 41 pregnant women with confirmed A(H1N1) pdm09 infection. Of them, 12 died (D), 29 survived (S), and 17 remained uninfected and served as controls (C). Antiviral response was evaluated for IFN-β expression and gene expression profiles of cytokines (TNF-α, IL-6, IL-12, TGF-β) and chemokines (IL-8, RANTES, MCP-1, IP-10), and the viral Matrix (M1) gene was quantified and normalized using the housekeeping gene product β-actin mRNA. Results: Higher IL-8 and TNF-α mRNA expression were found in D and S compared with C, while IL-6 showed higher expression in D. Interestingly, these results were associated with a decrease in the anti-inflammatory response of TGF-β mRNA and IFN-β. These alterations would lead to an imbalance in the immune response of those patients. Conclusions: Pregnancy-related reductions in IFN-β and TGF-β expression levels and elevated levels of pro-inflammatory cytokines could explain the increased severity of infection and death of pregnant women. These findings may help improve the understanding of the high susceptibility and disease severity to influenza virus infection during pregnancy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
A(H1n1)Pdm09
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Chemokines
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Cytokines
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Influenza Virus
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Pregnant Women
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Salud Ocupacional
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Pregnant women infected with pandemic influenza A(H1N1)pdm09 virus showed differential immune response correlated with disease severity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-08T19:00:06Z
dc.journal.volume
64
dc.journal.pagination
52-58
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Periolo, Natalia. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud ; Argentina
dc.description.fil
Fil: Avaro, M.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud ; Argentina
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Fil: Czech, A.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud ; Argentina
dc.description.fil
Fil: Russo, M.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud ; Argentina
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Fil: Benedetti, E.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud ; Argentina
dc.description.fil
Fil: Pontoriero, A.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud ; Argentina
dc.description.fil
Fil: Campos, A.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud ; Argentina
dc.description.fil
Fil: Martinez Peralta, Liliana A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
dc.description.fil
Fil: Baumeister, Elsa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud ; Argentina
dc.journal.title
Journal of Clinical Virology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jcv.2015.01.009
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1386653215000219
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