Artículo
Clostridium perfringens type E virulence traits involved in gut colonization
Redondo, Leandro Martin
; Díaz Carrasco, Juan María
; Redondo, Enzo Alejandro
; Delgado, Fernando Oscar; Fernandez Miyakawa, Mariano Enrique
Fecha de publicación:
03/2015
Editorial:
Public Library of Science
Revista:
Plos One
ISSN:
1932-6203
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Clostridium perfringens type E disease in ruminants has been characterized by hemorrhagic enteritis or sudden death. Although type E isolates are defined by the production of alpha and iota toxin, little is known about the pathogenesis of C. perfringens type E infections. Thus far, the role of iota toxin as a virulence factor is unknown. In this report, iota toxin showed positive effects on adherence and colonization of C. perfringens type E while having negative effect on the adherence of type A cells. In-vitro and in-vivo models suggest that toxinotype E would be particularly adapted to exploit the changes induced by iota toxin in the surface of epithelial cells. In addition, type E strains produce metabolites that affected the growth of potential intra-specific competitors. These results suggest that the alteration of the enterocyte morphology induced by iota toxin concomitantly with the specific increase of type E cell adhesion and the strong intra-specific growth inhibition of other strains could be competitive traits inherent to type E isolates that improve its fitness within the bovine gut environment.
Palabras clave:
Clostridium
,
Toxin
,
Iota
,
Intestine
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Redondo, Leandro Martin; Díaz Carrasco, Juan María; Redondo, Enzo Alejandro; Delgado, Fernando Oscar; Fernandez Miyakawa, Mariano Enrique; Clostridium perfringens type E virulence traits involved in gut colonization; Public Library of Science; Plos One; 10; 3; 3-2015; 1-10; e0121305
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