Artículo

Protein tyrosine phosphatase 1B (PTP1B) is involved in the defective erythropoietic function of carbamylated erythropoietin

Chamorro, María EugeniaIcon ; Maltaneri, Romina EugeniaIcon ; Vittori, Daniela CeciliaIcon ; Nesse, Alcira BeatrizIcon
Fecha de publicación: 02/2015
Editorial: Pergamon-Elsevier Science Ltd
Revista: International Journal Of Biochemistry And Cellular Biology
ISSN: 1357-2725
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

• Epo induced prolonged phosphorylation of proliferation signals in UT-7 cells. • cEpo induced only transient phosphorylation of proliferative pathways. • PTP1B activity was significantly increased in cultures with cEpo. • PTP1B colocalized with both subunits of the heterodimeric receptor used by cEpo. • Phosphatases are involved in the inability of cEpo to act as an erythroid growth factor.
Palabras clave: Carbamylated Erythropoietin , Cell Proliferation , Erythropoietin , Ptp1b , Tyrosine Phosphatases
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/38152
DOI: http://dx.doi.org/10.1016/j.biocel.2015.01.019
URL: https://www.sciencedirect.com/science/article/pii/S1357272515000291
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Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Chamorro, María Eugenia; Maltaneri, Romina Eugenia; Vittori, Daniela Cecilia; Nesse, Alcira Beatriz; Protein tyrosine phosphatase 1B (PTP1B) is involved in the defective erythropoietic function of carbamylated erythropoietin; Pergamon-Elsevier Science Ltd; International Journal Of Biochemistry And Cellular Biology; 61; 2-2015; 63-71
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