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dc.contributor.author
Mccarthy, Carly Jane
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dc.contributor.author
Tomasella, María Eugenia
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dc.contributor.author
Malet, Mariana
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dc.contributor.author
Seroogy, Kim B.
dc.contributor.author
Hökfelt, Tomas
dc.contributor.author
Villar, Marcelo Jose
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dc.contributor.author
Gebhart, G.F.
dc.contributor.author
Brumovsky, Pablo Rodolfo
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dc.date.available
2018-03-07T15:12:48Z
dc.date.issued
2016-05
dc.identifier.citation
Mccarthy, Carly Jane; Tomasella, María Eugenia; Malet, Mariana; Seroogy, Kim B.; Hökfelt, Tomas; et al.; Axotomy of tributaries of the pelvic and pudendal nerves induces changes in the neurochemistry of mouse dorsal root ganglion neurons and the spinal cord; Springer Heidelberg; Brain Structure & Function; 221; 4; 5-2016; 1985-2004
dc.identifier.issn
1863-2653
dc.identifier.uri
http://hdl.handle.net/11336/38120
dc.description.abstract
Using immunohistochemical techniques, we characterized changes in the expression of several neurochemical markers in lumbar 4-sacral 2 (L4–S2) dorsal root ganglion (DRG) neuron profiles (NPs) and the spinal cord of BALB/c mice after axotomy of the L6 and S1 spinal nerves, major tributaries of the pelvic (targeting pelvic visceral organs) and pudendal (targeting perineum and genitalia) nerves. Sham animals were included. Expression of cyclic AMP-dependent transcription factor 3 (ATF3), calcitonin gene-related peptide (CGRP), transient receptor potential cation channel subfamily V, member 1 (TRPV1), tyrosine hydroxylase (TH) and vesicular glutamate transporters (VGLUT) types 1 and -2 was analysed seven days after injury. L6–S1 axotomy induced dramatic de novo expression of ATF3 in many L6–S1 DRG NPs, and parallel significant downregulations in the percentage of CGRP-, TRPV1-, TH- and VGLUT2-immunoreactive (IR) DRG NPs, as compared to their expression in uninjured DRGs (contralateral L6–S1-AXO; sham mice); VGLUT1 expression remained unaltered. Sham L6–S1 DRGs only showed a small ipsilateral increase in ATF3-IR NPs (other markers were unchanged). L6–S1-AXO induced de novo expression of ATF3 in several lumbosacral spinal cord motoneurons and parasympathetic preganglionic neurons; in sham mice the effect was limited to a few motoneurons. Finally, a moderate decrease in CGRP- and TRPV1-like-immunoreactivities was observed in the ipsilateral superficial dorsal horn neuropil. In conclusion, injury of a mixed visceral/non-visceral nerve leads to considerable neurochemical alterations in DRGs matched, to some extent, in the spinal cord. Changes in these and potentially other nociception-related molecules could contribute to pain due to injury of nerves in the abdominopelvic cavity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Heidelberg
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cgrp
dc.subject
Glutamate
dc.subject
Nerve Injury
dc.subject
Trpv1
dc.subject
Visceral Pain
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Axotomy of tributaries of the pelvic and pudendal nerves induces changes in the neurochemistry of mouse dorsal root ganglion neurons and the spinal cord
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-06T17:44:44Z
dc.identifier.eissn
1863-2661
dc.journal.volume
221
dc.journal.number
4
dc.journal.pagination
1985-2004
dc.journal.pais
Alemania
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dc.description.fil
Fil: Mccarthy, Carly Jane. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
dc.description.fil
Fil: Tomasella, María Eugenia. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Malet, Mariana. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Seroogy, Kim B.. University of Cincinnati; Estados Unidos
dc.description.fil
Fil: Hökfelt, Tomas. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
dc.description.fil
Fil: Villar, Marcelo Jose. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Gebhart, G.F.. University of Pittsburgh; Estados Unidos
dc.description.fil
Fil: Brumovsky, Pablo Rodolfo. University of Pittsburgh; Estados Unidos. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Brain Structure & Function
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00429-015-1019-6
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00429-015-1019-6
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