Artículo
Effects of detyrosinated tubulin on Na+,K+-ATPase activity and erythrocyte function in hypertensive subjects
Amaiden, Marina Rafaela
; Santander, Verónica Silvina
; Monesterolo, Noelia Edith
; Nigra, Ayelén Denise
; Rivelli Antonelli, Juan Franco
; Campetelli, Alexis Nazareno
; Pie, Juan; Casale, Cesar Horacio
Fecha de publicación:
01/2015
Editorial:
Elsevier Science
Revista:
FEBS Letters
ISSN:
0014-5793
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Formation of tubulin/Na+,K+-ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development.
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Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Amaiden, Marina Rafaela; Santander, Verónica Silvina; Monesterolo, Noelia Edith; Nigra, Ayelén Denise; Rivelli Antonelli, Juan Franco; et al.; Effects of detyrosinated tubulin on Na+,K+-ATPase activity and erythrocyte function in hypertensive subjects; Elsevier Science; FEBS Letters; 589; 3; 1-2015; 364-373
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