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dc.contributor.author
Amaro González, Daniel
dc.contributor.author
Mabe, Guillermo Domingo
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Zabaloy, Marcelo Santiago
dc.contributor.author
Brignole, Esteban Alberto
dc.date.available
2018-03-02T19:15:58Z
dc.date.issued
2000-06
dc.identifier.citation
Amaro González, Daniel; Mabe, Guillermo Domingo; Zabaloy, Marcelo Santiago; Brignole, Esteban Alberto; Gas antisolvent crystallization of organic salts from aqueous solutions; Elsevier Science; Journal of Supercritical Fluids; 17; 3; 6-2000; 249-258
dc.identifier.issn
0896-8446
dc.identifier.uri
http://hdl.handle.net/11336/37705
dc.description.abstract
The selection of process conditions for the crystallization of an organic salt for pharmaceutical applications is studied in the present work. The crystallization process is carried out using the gas anti-solvent (GAS) technique to obtain particles with specific size and size distribution. The application of this process to organic salt aqueous solutions requires the use of cosolvents to increase the solubility of the antisolvent gas in the aqueous phase. The solubility of lobenzarit has been measured in water, methanol and water + methanol mixtures. The low solubility of lobenzarit in organic solvents is taken into account in the selection of the process scheme. Favorable operating conditions are found on the basis of a group contribution with association equation of state coupled with a non-linear optimizer. The feasibility of the proposed scheme and operating conditions are confirmed by experimental studies in a high pressure crystallizer, using CO2 as the antisolvent agent. The particles morphology is found to be strongly dependent on the feed capillary diameter.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antisolvent
dc.subject
Aqueous Mixtures
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Crystallization
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Lobenzarit
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Methanol
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Solubility
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Supercritical Fluids
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Otras Ingeniería Química
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Ingeniería Química
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Gas antisolvent crystallization of organic salts from aqueous solutions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-11-24T13:57:07Z
dc.journal.volume
17
dc.journal.number
3
dc.journal.pagination
249-258
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Amaro González, Daniel. Centro de Quimica Farmaceutica; Cuba
dc.description.fil
Fil: Mabe, Guillermo Domingo. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
dc.description.fil
Fil: Zabaloy, Marcelo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil
Fil: Brignole, Esteban Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur; Argentina
dc.journal.title
Journal of Supercritical Fluids
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S089684469900056X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/S0896-8446(99)00056-X
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