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dc.contributor.author
Salva, Maria Susana  
dc.contributor.author
Alvarez, Gladis Susana  
dc.date.available
2018-02-28T20:41:45Z  
dc.date.issued
2017-05  
dc.identifier.citation
Salva, Maria Susana; Alvarez, Gladis Susana; The role of microbiota and immunobiotics in granulopoiesis of immunocompromised hosts; Frontiers in Bioscience; Frontiers in Immunology; 8; 5-2017; 1-6  
dc.identifier.uri
http://hdl.handle.net/11336/37499  
dc.description.abstract
The number of granulocytes is maintained by a regulated balance between granulopoiesis in the bone marrow and clearance and destruction in peripheral tissues. Granulopoiesis plays a fundamental role in the innate immune response. Therefore, factors affecting the normal granulopoiesis lead to alterations in innate defenses and reduce the resistance against infections. In this study, we give a description on recent advances regarding the molecular and cellular events that regulate steady-state and emergency granulopoiesis, which are crucial processes for the generation of protective innate immune responses. Particular attention will be given to emergency granulopoiesis alterations in immunosuppression states caused by malnutrition and chemotherapy. The role of microbiota in maintaining a steady-state granulopoiesis and the immunological mechanisms involved are also discussed. Moreover, we describe the findings of our laboratory demonstrating that the dietary supplementation with immunobiotics is an interesting alternative to improve steady-state and emergency granulopoiesis, the respiratory innate immune response, and the resistance against respiratory pathogens in immunocompromised hosts.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Frontiers in Bioscience  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Granulopoiesis  
dc.subject
Immunobiotics  
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Immunocompromised Hosts  
dc.subject
Lactobacillus Rhamnosus Crl1505  
dc.subject
Respiratory Infections  
dc.subject.classification
Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
The role of microbiota and immunobiotics in granulopoiesis of immunocompromised hosts  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-07-13T18:58:53Z  
dc.identifier.eissn
1664-3224  
dc.journal.volume
8  
dc.journal.pagination
1-6  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina  
dc.description.fil
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina  
dc.journal.title
Frontiers in Immunology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fimmu.2017.00507  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2017.00507/full