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dc.contributor.author Salva, Maria Susana
dc.contributor.author Alvarez, Gladis Susana
dc.date.available 2018-02-28T20:41:45Z
dc.date.issued 2017-05
dc.identifier.citation Salva, Maria Susana; Alvarez, Gladis Susana; The role of microbiota and immunobiotics in granulopoiesis of immunocompromised hosts; Frontiers in Bioscience; Frontiers in Immunology; 8; 5-2017; 1-6
dc.identifier.uri http://hdl.handle.net/11336/37499
dc.description.abstract The number of granulocytes is maintained by a regulated balance between granulopoiesis in the bone marrow and clearance and destruction in peripheral tissues. Granulopoiesis plays a fundamental role in the innate immune response. Therefore, factors affecting the normal granulopoiesis lead to alterations in innate defenses and reduce the resistance against infections. In this study, we give a description on recent advances regarding the molecular and cellular events that regulate steady-state and emergency granulopoiesis, which are crucial processes for the generation of protective innate immune responses. Particular attention will be given to emergency granulopoiesis alterations in immunosuppression states caused by malnutrition and chemotherapy. The role of microbiota in maintaining a steady-state granulopoiesis and the immunological mechanisms involved are also discussed. Moreover, we describe the findings of our laboratory demonstrating that the dietary supplementation with immunobiotics is an interesting alternative to improve steady-state and emergency granulopoiesis, the respiratory innate immune response, and the resistance against respiratory pathogens in immunocompromised hosts.
dc.format application/pdf
dc.language.iso eng
dc.publisher Frontiers in Bioscience
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject GRANULOPOIESIS
dc.subject IMMUNOBIOTICS
dc.subject IMMUNOCOMPROMISED HOSTS
dc.subject LACTOBACILLUS RHAMNOSUS CRL1505
dc.subject RESPIRATORY INFECTIONS
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title The role of microbiota and immunobiotics in granulopoiesis of immunocompromised hosts
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-07-13T18:58:53Z
dc.identifier.eissn 1664-3224
dc.journal.volume 8
dc.journal.pagination 1-6
dc.journal.pais Estados Unidos
dc.description.fil Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.journal.title Frontiers in Immunology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fimmu.2017.00507
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2017.00507/full


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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)