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dc.contributor.author
Cort, Aysegul
dc.contributor.author
Ozben, Tomris
dc.contributor.author
Sansone, Anna
dc.contributor.author
Barata Vallejo, Sebastian
dc.contributor.author
Chatgilialoglu, Chryssostomos
dc.contributor.author
Ferreri, Carla
dc.date.available
2018-02-28T18:41:26Z
dc.date.issued
2015-01
dc.identifier.citation
Cort, Aysegul; Ozben, Tomris; Sansone, Anna; Barata Vallejo, Sebastian; Chatgilialoglu, Chryssostomos; et al.; Bleomycin-induced trans lipid formation in cell membranes and in liposome models; Royal Society of Chemistry; Organic & Biomolecular Chemistry; 13; 4; 1-2015; 1100-1105
dc.identifier.issn
1477-0520
dc.identifier.uri
http://hdl.handle.net/11336/37421
dc.description.abstract
Cell cultures of NTera-2 cells incubated with bleomycin and liposomes as biomimetic models of cell membranes were used for examining some novel aspects of drug-metal induced reactivity with unsaturated lipids under oxidative conditions. In cell cultures, bleomycin was found for the first time to cause the formation of trans fatty acids. The chemical basis of this transformation was ascertained by liposome experiments, using bleomycin-iron complexes in the presence of thiol as a reducing agent that by incubation at 37 °C gave rise to the thiyl radical-catalysed double bond isomerisation of membrane phospholipids. The effect of oxygen and reagent concentrations on the reaction outcome was studied. An interesting scenario of free radical reactivity is proposed, which can be relevant for understanding the role of membrane lipids in antitumoral treatments and drug carrier interaction.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Biomimetics
dc.subject
Fatty Acids
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Free Radicals
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Membrane Lipids
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Bleomycin-induced trans lipid formation in cell membranes and in liposome models
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-02-28T14:10:44Z
dc.journal.volume
13
dc.journal.number
4
dc.journal.pagination
1100-1105
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Cort, Aysegul. Akdeniz University. Faculty of Medicine; Turquía. Consiglio Nazionale delle Ricerche; Italia
dc.description.fil
Fil: Ozben, Tomris. Akdeniz University. Faculty of Medicine; Turquía
dc.description.fil
Fil: Sansone, Anna. Consiglio Nazionale delle Ricerche; Italia
dc.description.fil
Fil: Barata Vallejo, Sebastian. Consiglio Nazionale delle Ricerche; Italia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Chatgilialoglu, Chryssostomos. Demokritos National Centre For Scientific Research; Grecia
dc.description.fil
Fil: Ferreri, Carla. Consiglio Nazionale delle Ricerche; Italia
dc.journal.title
Organic & Biomolecular Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/c4ob01924e
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2015/OB/C4OB01924E
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