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dc.contributor.author Chierentin, Lucas
dc.contributor.author Garnero, Claudia
dc.contributor.author Chattah, Ana Karina
dc.contributor.author Delvadia, Poonam
dc.contributor.author Karnes, Thomas
dc.contributor.author Longhi, Marcela Raquel
dc.contributor.author Salgado, Hérida Regina Nunes
dc.date.available 2018-02-27T19:45:26Z
dc.date.issued 2015-01
dc.identifier.citation Chierentin, Lucas; Garnero, Claudia; Chattah, Ana Karina; Delvadia, Poonam; Karnes, Thomas; et al.; Influence of β-cyclodextrin on the Properties of Norfloxacin Form A; Springer; AAPS Pharmscitech; 16; 3; 1-2015; 683-691
dc.identifier.issn 1530-9932
dc.identifier.uri http://hdl.handle.net/11336/37312
dc.description.abstract Cyclodextrins are able to form host–guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and β-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and β-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with β-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of β-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug.
dc.format application/pdf
dc.language.iso eng
dc.publisher Springer
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject BIOASSAY
dc.subject COMPLEXATION
dc.subject INTRINSIC DISSOLUTION
dc.subject NORFLOXACIN
dc.subject Β-CYCLODEXTRIN
dc.subject.classification Nano-materiales
dc.subject.classification Nanotecnología
dc.subject.classification INGENIERÍAS Y TECNOLOGÍAS
dc.title Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-02-27T14:17:30Z
dc.journal.volume 16
dc.journal.number 3
dc.journal.pagination 683-691
dc.journal.pais Alemania
dc.journal.ciudad Berlin
dc.description.fil Fil: Chierentin, Lucas. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
dc.description.fil Fil: Delvadia, Poonam. Virginia Commonwealth University; Estados Unidos
dc.description.fil Fil: Karnes, Thomas. Virginia Commonwealth University; Estados Unidos
dc.description.fil Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil Fil: Salgado, Hérida Regina Nunes. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.journal.title AAPS Pharmscitech
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444636/
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1208%2Fs12249-014-0259-8
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1208/s12249-014-0259-8
dc.conicet.fuente individual


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    Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)