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dc.contributor.author
Le Douaron, Gael
dc.contributor.author
Ferrié, Laurent
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Sepulveda Diaz, Julia E.
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Seon Méniel, Blandine
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Acuña, Leonardo
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Raisman Vozari, Rita
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Michel, Patrick P.
dc.contributor.author
Figadere, Bruno
dc.date.available
2018-02-27T15:23:32Z
dc.date.issued
2017-09
dc.identifier.citation
Le Douaron, Gael; Ferrié, Laurent ; Sepulveda Diaz, Julia E.; Seon Méniel, Blandine ; Acuña, Leonardo; et al.; Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease; American Chemical Society; ACS Chemical Neuroscience; 8; 10; 9-2017; 2347-2347
dc.identifier.issn
1948-7193
dc.identifier.uri
http://hdl.handle.net/11336/37253
dc.description.abstract
Parkinson's disease (PD) is a chronic degenerative disorder characterized by typical motor symptoms caused by the death of dopamine (DA) neurons in the midbrain and ensuing shortage of DA in the striatum, at the level of nerve terminals. No curative treatment is presently available for PD in clinical practice. In our search for neuroprotectants in PD, we generated new 1,4,8-triazaphenanthrenes by combining 6-endo-dig-cycloisomerization of propargylquinoxalines and Suzuki or Sonogashira cross-coupling reactions. Neuroprotection assessment of newly synthesized 1,4,8-triazaphenanthrenes in a PD cellular model resulted in the discovery of a new hit compound PPQ (5m). Neuroprotection by 5m was concentration-dependent and the result of a combined effect on intracellular calcium release channels and astroglial cells. Of interest, 5m also counteracted DA cell loss in a mouse model of PD, making this molecule a promising candidate for PD treatment.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Medicinal Chemistry
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Neurodegenerative Diseases
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Phenotypic Screening
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Primary Neuronal Cultures
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Suzuki Coupling Reaction
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-11-03T19:10:11Z
dc.journal.volume
8
dc.journal.number
10
dc.journal.pagination
2347-2347
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Le Douaron, Gael. Universite Paris Sud; Francia. Universite Pierre et Marie Curie; Francia
dc.description.fil
Fil: Ferrié, Laurent. Universite Paris Sud; Francia
dc.description.fil
Fil: Sepulveda Diaz, Julia E.. Universite Pierre et Marie Curie; Francia
dc.description.fil
Fil: Seon Méniel, Blandine. Universite Paris Sud; Francia
dc.description.fil
Fil: Acuña, Leonardo. Universite Pierre et Marie Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Raisman Vozari, Rita. Universite Pierre et Marie Curie; Francia
dc.description.fil
Fil: Michel, Patrick P.. Universite Pierre et Marie Curie; Francia
dc.description.fil
Fil: Figadere, Bruno. Universite Paris Sud; Francia
dc.journal.title
ACS Chemical Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acschemneuro.7b00352
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acschemneuro.7b00352
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