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dc.contributor.author Le Douaron, Gael
dc.contributor.author Ferrié, Laurent
dc.contributor.author Sepulveda Diaz, Julia E.
dc.contributor.author Seon Méniel, Blandine
dc.contributor.author Acuña, Leonardo
dc.contributor.author Raisman Vozari, Rita
dc.contributor.author Michel, Patrick P.
dc.contributor.author Figadere, Bruno
dc.date.available 2018-02-27T15:23:32Z
dc.date.issued 2017-09
dc.identifier.citation Le Douaron, Gael; Ferrié, Laurent ; Sepulveda Diaz, Julia E.; Seon Méniel, Blandine ; Acuña, Leonardo; et al.; Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease; American Chemical Society; ACS Chemical Neuroscience; 8; 10; 9-2017; 2347-2347
dc.identifier.issn 1948-7193
dc.identifier.uri http://hdl.handle.net/11336/37253
dc.description.abstract Parkinson's disease (PD) is a chronic degenerative disorder characterized by typical motor symptoms caused by the death of dopamine (DA) neurons in the midbrain and ensuing shortage of DA in the striatum, at the level of nerve terminals. No curative treatment is presently available for PD in clinical practice. In our search for neuroprotectants in PD, we generated new 1,4,8-triazaphenanthrenes by combining 6-endo-dig-cycloisomerization of propargylquinoxalines and Suzuki or Sonogashira cross-coupling reactions. Neuroprotection assessment of newly synthesized 1,4,8-triazaphenanthrenes in a PD cellular model resulted in the discovery of a new hit compound PPQ (5m). Neuroprotection by 5m was concentration-dependent and the result of a combined effect on intracellular calcium release channels and astroglial cells. Of interest, 5m also counteracted DA cell loss in a mouse model of PD, making this molecule a promising candidate for PD treatment.
dc.format application/pdf
dc.language.iso eng
dc.publisher American Chemical Society
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Medicinal Chemistry
dc.subject Neurodegenerative Diseases
dc.subject Phenotypic Screening
dc.subject Primary Neuronal Cultures
dc.subject Suzuki Coupling Reaction
dc.subject.classification Otras Ciencias Biológicas
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.subject.classification Otras Ciencias Químicas
dc.subject.classification Ciencias Químicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Correction to: Identification of a novel 1,4,8-triazaphenanthrene derivative as a neuroprotectant for dopamine neurons vulnerable in Parkinson's disease
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-11-03T19:10:11Z
dc.journal.volume 8
dc.journal.number 10
dc.journal.pagination 2347-2347
dc.journal.pais Estados Unidos
dc.description.fil Fil: Le Douaron, Gael. Universite Paris Sud; Francia. Universite Pierre et Marie Curie; Francia
dc.description.fil Fil: Ferrié, Laurent. Universite Paris Sud; Francia
dc.description.fil Fil: Sepulveda Diaz, Julia E.. Universite Pierre et Marie Curie; Francia
dc.description.fil Fil: Seon Méniel, Blandine. Universite Paris Sud; Francia
dc.description.fil Fil: Acuña, Leonardo. Universite Pierre et Marie Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Raisman Vozari, Rita. Universite Pierre et Marie Curie; Francia
dc.description.fil Fil: Michel, Patrick P.. Universite Pierre et Marie Curie; Francia
dc.description.fil Fil: Figadere, Bruno. Universite Paris Sud; Francia
dc.journal.title ACS Chemical Neuroscience
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acschemneuro.7b00352
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acschemneuro.7b00352


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)