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dc.contributor.author
Luengas, Sandra L. Pena
dc.contributor.author
Marin, Gustavo Horacio
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dc.contributor.author
Aviles, Kevin
dc.contributor.author
Acuña, Ricardo Cruz
dc.contributor.author
Roque, Gustavo
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Nieto, Felipe Rodríguez
dc.contributor.author
Sánchez, Francisco Homero
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dc.contributor.author
Tarditi, Adrián
dc.contributor.author
Rivera, Luis
dc.contributor.author
Mansilla, Eduardo
dc.date.available
2018-02-26T19:04:49Z
dc.date.issued
2014-12
dc.identifier.citation
Luengas, Sandra L. Pena; Marin, Gustavo Horacio; Aviles, Kevin; Acuña, Ricardo Cruz; Roque, Gustavo; et al.; Enhanced singlet oxygen production by photodynamic therapy and a novel method for its intracellular measurement; Mary Ann Liebert; Cancer Biotherapy And Radiopharmaceuticals; 29; 10; 12-2014; 435-443
dc.identifier.issn
1084-9785
dc.identifier.uri
http://hdl.handle.net/11336/37144
dc.description.abstract
The generation of singlet oxygen (SO) in the presence of specific photosensitizers (PSs) or semiconductor quantum dots (QDs) and its application in photodynamic therapy (PDT) is of great interest to develop cancer therapies with no need of surgery, chemotherapy, and/or radiotherapy. This work was focused on the identification of the main factors leading to the enhancement of SO production using Rose Bengal (RB), and Methylene Blue (MB) as PS species in organic and aqueous mediums. Subsequently, the capacity of zinc oxide (ZnO), zinc sulfide (ZnS), and ZnO/ZnS core-shell QDs as well as manganese (Mn+2) doped ZnO and ZnS nanoparticles (NPs) as potential PS was also investigated. Many variable parameters such as type of quencher, PSs, NPs, as well as its different concentrations, light source, excitation wavelength, reaction time, distance from light source, and nature of solvent were used. The degradation kinetics of the quenchers generated by SO species and the corresponding quantum yields were determined by monitoring the photo-oxidation of the chemical quencher and measuring its disappearance by fluorometry and spectrophotometry in the presence of NPs. Small intracellular changes of SO induced by these metal Zn (zinc) NPs and PDT could execute and accelerate deadly programs in these leukemic cells, providing in this way an innovative modality of treatment. In order to perform further more specific in vitro cytotoxic studies on B-chronic lymphocytic leukemia cells exposed to Zn NPs and PDT, we needed first to measure and ascertain those possible intracellular SO variations generated by this type of treatment; for this purpose, we have also developed and tested a novel method first described by us.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Mary Ann Liebert
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
B-Cll
dc.subject
Chemotherapy
dc.subject
Lymphoma
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Targeted Therapy
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Treatment
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Enhanced singlet oxygen production by photodynamic therapy and a novel method for its intracellular measurement
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-23T14:03:34Z
dc.journal.volume
29
dc.journal.number
10
dc.journal.pagination
435-443
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Luengas, Sandra L. Pena. Universidad de Puerto Rico; Puerto Rico
dc.description.fil
Fil: Marin, Gustavo Horacio. Cucaiba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Aviles, Kevin. Universidad de Puerto Rico; Puerto Rico
dc.description.fil
Fil: Acuña, Ricardo Cruz. Universidad de Puerto Rico; Puerto Rico
dc.description.fil
Fil: Roque, Gustavo. Cucaiba; Argentina
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Fil: Nieto, Felipe Rodríguez. Universidad Nacional Arturo Jauretche; Argentina
dc.description.fil
Fil: Sánchez, Francisco Homero. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Tarditi, Adrián. Cucaiba; Argentina
dc.description.fil
Fil: Rivera, Luis. Universidad de Puerto Rico; Puerto Rico
dc.description.fil
Fil: Mansilla, Eduardo. Cucaiba; Argentina
dc.journal.title
Cancer Biotherapy And Radiopharmaceuticals
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1089/cbr.2014.1718
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/cbr.2014.1718
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