Artículo
In vivo antileishmanial efficacy of miltefosine against Leishmania (Leishmania) amazonensis
Garcia Bustos, Maria Fernanda
; Barrio, Alejandra; Prieto, Gabriela G.; De Raspi, Emma M.; Cimino, Rubén Oscar
; Cardozo, Rubén Marino; Parada, Luis Antonio
; Yeo, Matthew; Soto, Jaime; Uncos, Delfor Alejandro
; Parodi Ramoneda, Cecilia María
; Basombrío, Miguel Ángel Manuel
Fecha de publicación:
12/2014
Editorial:
American Society of Parasitologists
Revista:
Journal of Parasitology
ISSN:
0022-3395
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Leishmaniasis, a disease caused by parasites of the Leishmania genus, constitutes a significant health and social problem in many countries and is increasing worldwide. The conventional treatment, meglumine antimoniate (MA), presents numerous disadvantages, including invasiveness, toxicity, and frequent therapeutic failure, justifying the attempts at finding alternatives to the first-line therapy. We have studied the comparative long-term efficacy of MA against miltefosine (MF) in Leishmania infection in experimental mice. The criteria for efficacy evaluation were footpad lesion size, anti-Leishmania antibodies level, histopathology of the site of inoculation (right footpad, RFP), splenic index (SI), and the presence of parasites in RFP, spleen, and liver, determined by polymerase chain reaction (PCR). Swiss mice, infected with Leishmania (Leishmania) amazonensis were treated, at different time points (5 and 40 days after infection) with either MA or MF. The efficacy of MF was better than that of MA for inhibiting lesions and for reducing tissue damage and presence/load of amastigotes in spleen and liver. Moreover, early administration of MF produced a clear reduction in splenomegaly and was equal in reducing antibody titles in comparison with MA. Our results demonstrated that MF is an effective and safe therapeutic alternative for leishmaniasis by L. (L.) amazonensis and is more efficacious than MA.
Palabras clave:
Miltefosine
,
Leishmania
,
Amazonensis
,
Efficacy
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Garcia Bustos, Maria Fernanda; Barrio, Alejandra; Prieto, Gabriela G.; De Raspi, Emma M.; Cimino, Rubén Oscar; et al.; In vivo antileishmanial efficacy of miltefosine against Leishmania (Leishmania) amazonensis; American Society of Parasitologists; Journal of Parasitology; 100; 6; 12-2014; 840-847
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