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dc.contributor.author
Babot, Jaime Daniel
dc.contributor.author
Argañaraz Martínez, Fernando Eloy
dc.contributor.author
Lorenzo Pisarello, Maria Jose
dc.contributor.author
Apella, Maria Cristina
dc.contributor.author
Perez Chaia, Adriana Beatriz
dc.date.available
2018-02-19T19:38:30Z
dc.date.issued
2016-06
dc.identifier.citation
Babot, Jaime Daniel; Argañaraz Martínez, Fernando Eloy; Lorenzo Pisarello, Maria Jose; Apella, Maria Cristina; Perez Chaia, Adriana Beatriz; Cytotoxic damage of soybean agglutinin on intestinal epithelial cells of broiler chicks: In vitro protection by Bifidobacterium infantis CRL1395; Wiley Blackwell Publishing, Inc; FEMS Microbiology Letters; 363; 12; 6-2016; 1-7
dc.identifier.issn
0378-1097
dc.identifier.uri
http://hdl.handle.net/11336/36753
dc.description.abstract
Plant lectins, which are proteins/glycoproteins present in a wide range of vegetables, fruits, cereals and beans, are resistant to digestive enzymes and food cooking temperatures. They bind reversibly to specific glycosidic residues expressed on the membrane of intestinal epithelial cells (IEC) and cause anti-nutritional effects in humans and animals. Soybean lectin (SBA) has been detected in poultry diets, and its ability to bind to the intestinal epithelium has been reported. The development of new methods for removing SBA from feeds or to prevent interaction with the intestinal mucosa is of interest. In this study, the in vitro cytotoxicity of SBA on IEC of chicks was demonstrated for the first time. The LD50, assessed after 2 h exposure of IEC to SBA, was 6.13 μg mL-1. The ability of Bifidobacterium infantis CRL1395 to bind SBA on the bacterial envelope was confirmed, and prevention of IEC cytotoxicity by lectin removal was demonstrated. Safety of B. infantis CRL1395, resistance to gastrointestinal stress and adhesion were also determined. It was concluded that the early administration of B. infantis CRL1395 to chicks would effectively reduce the toxicity of SBA. Besides, it would favour the colonization of the gut with a beneficial microbiota.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bifidobacterium
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Broiler Chicks
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Cytotoxicity
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Intestinal Epithelial Cells
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Probiotics
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Soybean Agglutinin
dc.subject.classification
Otras Biotecnología Agropecuaria
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Biotecnología Agropecuaria
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.subject.classification
Otras Biotecnología Agropecuaria
dc.subject.classification
Biotecnología Agropecuaria
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
Cytotoxic damage of soybean agglutinin on intestinal epithelial cells of broiler chicks: In vitro protection by Bifidobacterium infantis CRL1395
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-04T18:00:59Z
dc.journal.volume
363
dc.journal.number
12
dc.journal.pagination
1-7
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Babot, Jaime Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Argañaraz Martínez, Fernando Eloy. Universidad Nacional de Tucumán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lorenzo Pisarello, Maria Jose. Universidad Nacional de Tucumán; Argentina. Universidad Nacional de Tucumán; Argentina
dc.description.fil
Fil: Apella, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Universidad Nacional de Tucumán; Argentina
dc.description.fil
Fil: Perez Chaia, Adriana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Universidad Nacional de Tucumán; Argentina
dc.journal.title
FEMS Microbiology Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/femsle/article/363/12/fnw114/2570349
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/femsle/fnw114