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dc.contributor.author
Boiani, Lucia
dc.contributor.author
Davies, Carolina
dc.contributor.author
Arredondo, Carolina
dc.contributor.author
Porcal, Williams
dc.contributor.author
Merlino, Alicia
dc.contributor.author
Gerpe, Alejandra
dc.contributor.author
Boiani, Mariana
dc.contributor.author
Pacheco, José Pedro
dc.contributor.author
Basombrío, Miguel Ángel Manuel
dc.contributor.author
Cerecetto, Hugo
dc.contributor.author
González, Mercedes
dc.date.available
2018-02-19T17:54:35Z
dc.date.issued
2008-10
dc.identifier.citation
Boiani, Lucia; Davies, Carolina; Arredondo, Carolina; Porcal, Williams; Merlino, Alicia; et al.; In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease; Elsevier; European Journal of Medical Chemistry; 43; 10; 10-2008; 2229-2237
dc.identifier.issn
0223-5234
dc.identifier.uri
http://hdl.handle.net/11336/36728
dc.description.abstract
5-Arylethenylbenzofuroxan derivatives with high in vitro anti-Trypanosoma cruzi activity were studied in vivo using acute murine models of Chagas' disease. The selected compounds, as pure isomeric forms, 1, 2, 3 and 4, or as equimolecular mixture of geometric isomers, 1:2, 3:4, 5:6 were studied against different T. cruzi strains. Consequently, Tulahuen 2 strain, Colombiana strain (resistant to Nifurtimox and Benznidazole), and two different wild strains, one isolated from the wild reservoir Didelphis marsupialis and another one from Uruguayan patients, were selected. No relevant signs of in vivo toxicity were observed with the benzofuroxans orally administered. Compound 1 and the mixture of isomers 1:2 were the best for treating infection against the four studied strains.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Arylethenylbenzofuroxan
dc.subject
Chagas
dc.subject
In Vivo Studies
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-11-03T19:09:25Z
dc.journal.volume
43
dc.journal.number
10
dc.journal.pagination
2229-2237
dc.journal.pais
Francia
dc.description.fil
Fil: Boiani, Lucia. Universidad de la República; Uruguay
dc.description.fil
Fil: Davies, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
dc.description.fil
Fil: Arredondo, Carolina. Universidad de la República; Uruguay
dc.description.fil
Fil: Porcal, Williams. Universidad de la República; Uruguay
dc.description.fil
Fil: Merlino, Alicia. Universidad de la República; Uruguay
dc.description.fil
Fil: Gerpe, Alejandra. Universidad de la República; Uruguay
dc.description.fil
Fil: Boiani, Mariana. Universidad de la República; Uruguay
dc.description.fil
Fil: Pacheco, José Pedro. Universidad de la República; Uruguay
dc.description.fil
Fil: Basombrío, Miguel Ángel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
dc.description.fil
Fil: Cerecetto, Hugo. Universidad de la República; Uruguay
dc.description.fil
Fil: González, Mercedes. Universidad de la República; Uruguay
dc.journal.title
European Journal of Medical Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ejmech.2007.12.016
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0223523407004898
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