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dc.contributor.author
Balague, Claudia Elisabeht
dc.contributor.author
Stürtz, Nelson
dc.contributor.author
Rey, Rosario
dc.contributor.author
Silva, Clara del Valle
dc.contributor.author
Nader, Maria Elena Fatima
dc.contributor.author
Duffard, Ricardo Oscar
dc.contributor.author
Evangelista de Duffard, Ana Maria
dc.date.available
2018-02-19T17:54:06Z
dc.date.issued
2006-12
dc.identifier.citation
Balague, Claudia Elisabeht; Stürtz, Nelson; Rey, Rosario; Silva, Clara del Valle; Nader, Maria Elena Fatima; et al.; Aryloxoalcanoic compounds induce resistance to antibiotic therapy in urinary tract infection caused by Escherichia coli; Wiley Blackwell Publishing, Inc; Fems Immunology And Medical Microbiology; 48; 3; 12-2006; 337-346
dc.identifier.issn
0928-8244
dc.identifier.uri
http://hdl.handle.net/11336/36725
dc.description.abstract
Clofibric acid (CL) is a compound used to control hypertriglyceridemia, and ethacrynic acid (ET) is administered to enhance diuresis. These compounds are structurally analogous to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), as they have a chlorinated phenoxy moiety. As these agents are mainly excreted by the renal route, they could potentially coexist with Escherichia coli in the urinary tract of infected patients. Induction of the in vitro resistance of E. coli to hydrophilic antibiotics was determined by increasing the values of the minimum inhibitory concentration (2-40-fold). These results correlated with drastically inhibited expression of the hydrophilic bacterial channel OmpF. In vivo assays were performed in ascending urinary tract infection in female BALB/c mice. Treatment with the hydrophilic antibiotic cephalexin 25 mg kg -1 day-1 by the oral route diminished renal infection. The CFU mean values in the kidneys were between 75% and 89% lower than those in animals without treatment. Simultaneous exposure to CL (at a therapeutic dose, 28.6 mg kg-1 day-1) did not change the effect of the treatment. In contrast, ET at 2.9 mg kg-1 day-1 or 2,4-D at 70 mg kg-1 day-1 inhibited the antibiotic therapeutic effect. Moreover, 2,4-D dramatically increased bacterial infection after 9 days of exposure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
2,4-Dichlorophenoxyacetic Acid
dc.subject
Antibiotic Resistance
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Clofibric Acid
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Ethacrynic Acid
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Uropathogenic Escherichia Coli
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Uti Murine Model
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Otras Ciencias Biológicas
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Aryloxoalcanoic compounds induce resistance to antibiotic therapy in urinary tract infection caused by Escherichia coli
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-24T18:59:27Z
dc.journal.volume
48
dc.journal.number
3
dc.journal.pagination
337-346
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Balague, Claudia Elisabeht. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina
dc.description.fil
Fil: Stürtz, Nelson. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina
dc.description.fil
Fil: Rey, Rosario. Universidad Nacional de Tucumán; Argentina
dc.description.fil
Fil: Silva, Clara del Valle. Universidad Nacional de Tucumán; Argentina
dc.description.fil
Fil: Nader, Maria Elena Fatima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Duffard, Ricardo Oscar. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Evangelista de Duffard, Ana Maria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina
dc.journal.title
Fems Immunology And Medical Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1574-695X.2006.00153.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1574-695X.2006.00153.x/abstract


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