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Artículo

Parkinson's disease severity levels and MDS-Unified Parkinson's Disease Rating Scale

Martínez Martín, Pablo; Rodríguez Blázquez, Carmen; Alvarez, Mario; Arakaki, Tomoko; Campos Arillo, Víctor; Chaná, Pedro; Fernández, William; Garretto, Nelida; Martínez Castrillo, Juan Carlos; Rodríguez Violante, Mayela; Serrano Dueñas, Marcos; Ballesteros, Diego; Rojo Abuin, Jose Manuel; Chaudhuri, Kallol Ray; Merello, Marcelo JorgeIcon
Fecha de publicación: 11/2014
Editorial: Wiley-liss, Div John Wiley & Sons Inc
Revista: Movement Disorders
ISSN: 0885-3185
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias de la Salud

Resumen

Background Severity of PD is usually assessed by means of the motor and disability-based Hoehn and Yahr staging (HY), or clinician and patient global perceptions. Scores of more detailed assessments, as the MDS-UPDRS, have not been translated to a grading that allows assignment of score sections to severity levels. The objective of the present study is to determine cut-off points for PD severity levels based on the MDS-UPDRS. Methods International, observational study. Applied assessments were: HY, MDS-UPDRS, Clinical Impression for Severity Index, and Clinical and Patient Global Impression of Severity. The coincidence in severity level (mild, moderate, severe) of at least two clinical classifications plus the patient's gradation was considered “the criterion of severity”. Cut-off values for each MDS-UPDRS subscale was determined by triangulation of: 1) percentile 90 of the subscale total score; 2) receiver operating characteristic (ROC) analysis; and 3) ordinal logistic regression (OLR) model. Results Sample was composed of 452 consecutive PD patients without dementia, 55.3% males, age 65.1 ± 10.7 years and PD duration 8.7 ± 6.3 years. All HY stages were represented. The “criterion”, classified 275 patients (60.8% of the sample) as: mild PD, 149 (54.2%); moderate, 82 (29.8%); and severe, 44 (16%). The following MDS-UPDRS cut-off points between mild/moderate and moderate/severe levels were found: Part 1: 10/11 and 21/22; Part 2: 12/13 and 29/30; Part 3: 32/33 and 58/59; and Part 4: 4/5 and 12/13. Conclusion Cut-off points to classify PD patients as mild, moderate, or severe on the basis of their MDS-UPDRS scores are proposed.
Palabras clave: Pisa Syndrome , Mds-Updrs , Parkinson'S Disease , Teaching Neuroimages
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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URI: http://hdl.handle.net/11336/36592
DOI: http://dx.doi.org/10.1016/j.parkreldis.2014.10.026
URL: http://www.prd-journal.com/article/S1353-8020(14)00411-8/fulltext
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Martínez Martín, Pablo; Rodríguez Blázquez, Carmen; Alvarez, Mario; Arakaki, Tomoko; Campos Arillo, Víctor; et al.; Parkinson's disease severity levels and MDS-Unified Parkinson's Disease Rating Scale; Wiley-liss, Div John Wiley & Sons Inc; Movement Disorders; 21; 1; 11-2014; 50-54
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