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Artículo

Differential expression of the fractalkine chemokine receptor (CX3CR1) in human monocytes during differentiation

Panek, Cecilia AnalíaIcon ; Ramos, Maria VictoriaIcon ; Mejias, María PilarIcon ; Abrey Recalde, Maria JimenaIcon ; Fernández Brando, Romina JimenaIcon ; Gori, María SoledadIcon ; Salamone, Gabriela VeronicaIcon ; Palermo, Marina SandraIcon
Fecha de publicación: 12/2014
Editorial: Chinese Soc Immunology
Revista: Cellular & Molecular Immunology
ISSN: 1672-7681
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Circulating monocytes (Mos) may continuously repopulate macrophage (MAC) or dendritic cell (DC) populations to maintain homeostasis. MACs and DCs are specialized cells that play different and complementary immunological functions. Accordingly, they present distinct migratory properties. Specifically, whereas MACs largely remain in tissues, DCs are capable of migrating from peripheral tissues to lymphoid organs. The aim of this work was to analyze the expression of the fractalkine receptor (CX3CR1) during the monocytic differentiation process. Freshly isolated Mos express high levels of both CX3CR1 mRNA and protein. During the Mo differentiation process, CX3CR1 is downregulated in both DCs and MACs. However, MACs showed significantly higher CX3CR1 expression levels than did DC. We also observed an antagonistic CX3CR1 regulation by interferon (IFN)-γ and interleukin (IL)-4 during MAC activation through the classical and alternative MAC pathways, respectively. IFN-γ inhibited the loss of CX3CR1, but IL-4 induced it. Additionally, we demonstrated an association between CX3CR1 expression and apoptosis prevention by soluble fractalkine (sCX3CL1) in Mos, DCs and MACs. This is the first report demonstrating sequential and differential CX3CR1 modulation during Mo differentiation. Most importantly, we demonstrated a functional link between CX3CR1 expression and cell survival in the presence of sCX3CL1.
Palabras clave: Fractalkine Chemokine Receptor (Cx3cr1) , Monocytes
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/36442
DOI: http://dx.doi.org/10.1038/cmi.2014.116
URL: https://www.nature.com/articles/cmi2014116
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Panek, Cecilia Analía; Ramos, Maria Victoria; Mejias, María Pilar; Abrey Recalde, Maria Jimena; Fernández Brando, Romina Jimena; et al.; Differential expression of the fractalkine chemokine receptor (CX3CR1) in human monocytes during differentiation; Chinese Soc Immunology; Cellular & Molecular Immunology; 12; 12-2014; 669-680
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