Mostrar el registro sencillo del ítem

dc.contributor.author
Pazos Maidana, María Camila
dc.contributor.author
Sequeira, Gonzalo Ricardo
dc.contributor.author
Bocchicchio, Sebastian
dc.contributor.author
May, Maria
dc.contributor.author
Abramovich, Dalhia Nurit
dc.contributor.author
Parborell, Maria Fernanda Agustina
dc.contributor.author
Tesone, Marta
dc.contributor.author
Irusta, Griselda
dc.date.available
2018-02-12T15:50:34Z
dc.date.issued
2017-12-20
dc.identifier.citation
Pazos Maidana, María Camila; Sequeira, Gonzalo Ricardo; Bocchicchio, Sebastian; May, Maria; Abramovich, Dalhia Nurit; et al.; PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor; Wiley-liss, Div John Wiley & Sons Inc; Journal of Cellular Physiology; 20-12-2017
dc.identifier.issn
0021-9541
dc.identifier.uri
http://hdl.handle.net/11336/36419
dc.description.abstract
Ovarian cancer is the fifth leading cause of cancer-related deaths in women. In the past 20 years, the canonical types of drugs used to treat ovarian cancer have not been replaced and the survival rates have not changed. These facts show the clear need to find new therapeutic strategies for this illness. Thus, the aim of the present study was to investigate the effect of a gamma-secretase inhibitor (DAPT) in combination with the Platelet-derived growth factor B (PDGFB) on an ovarian cancer xenograft model. To achieve this goal, we analyzed the effect of the administration of DAPT alone and the co-administration of DAPT and recombinant PDGFB on parameters associated with tumour growth and angiogenesis in an orthotopic experimental model of ovarian cancer. We observed that the dose of DAPT used was ineffective to reduce ovarian tumour growth, but showed anticancer activity when co-administered with recombinant PDGFB. The administration of PDGFB alone normalized tumour vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. Our findings suggest that PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. We propose that this therapeutic strategy could be a new tool for ovarian cancer treatment and deserves further studies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/embargoedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Ovarian Cancer
dc.subject
Notch System
dc.subject
Pdgfb
dc.subject
Normalization
dc.subject
Angiogenesis
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Oncología
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-02-05T13:42:38Z
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.conicet.avisoEditorial
This is the pre-peer reviewed version of the following article:Pazos, M. C., et al. "PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma‐secretase inhibitor." Journal of cellular physiology (2017), which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/jcp.26404/abstract This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
dc.description.fil
Fil: Pazos Maidana, María Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Sequeira, Gonzalo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Bocchicchio, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: May, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.description.fil
Fil: Abramovich, Dalhia Nurit. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Parborell, Maria Fernanda Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Tesone, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Irusta, Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title
Journal of Cellular Physiology
dc.rights.embargoDate
2019-01-01
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1002/jcp.26404
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jcp.26404
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/29266203


Archivos asociados

 

Comunidades y colecciones

Mostrar el registro sencillo del ítem