Artículo

Invasive micropapillary carcinoma of the breast overexpresses MUC4 and is associated with poor outcome to adjuvant trastuzumab in HER2-positive breast cancer

Mercogliano, María FlorenciaIcon ; Inurrigarro, Gloria; de Martino, MaraIcon ; Venturutti, LeandroIcon ; Rivas, Martin AlfredoIcon ; Cordo Russo, Rosalia InesIcon ; Proietti Anastasi, Cecilia JazmínIcon ; Fernandez, Elmer AndresIcon ; Frahm, Isabel; Barchuk, Sabrina; Allemand, Daniel H.; Figurelli, Silvina; Gil Deza, Ernesto; Ares, Sandra; Gercovich, Felipe G.; Cortese, Eduardo; Amasino, Matías; Guzmán, Pablo; Roa, Juan C.; Elizalde, Patricia VirginiaIcon ; Schillaci, RoxanaIcon
Fecha de publicación: 12/2017
Editorial: BioMed Central
Revista: BMC Cancer
ISSN: 1471-2407
e-ISSN: 1471-2407
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Invasive micropapillary carcinoma of the breast (IMPC) is a histological tumor variant that occurs with low frequency characterized by an inside-out formation of tumor clusters with a pseudopapillary arrangement. IMPC is an aggressive tumor with poor clinical outcome. In addition, this histological subtype usually expresses human epidermal growth factor receptor 2 (HER2) which also correlates with a more aggressive tumor. In this work we studied the clinical significance of IMPC in HER2-positive breast cancer patients treated with adjuvant trastuzumab. We also analyzed mucin 4 (MUC4) expression as a novel biomarker to identify IMPC.
Palabras clave: Her2 , Invasive Micropapillary Carcinoma Of the Breast(Impc) , Mucin 4 (Muc4) , Trastuzumab
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/36418
URL: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3897-x
DOI: http://dx.doi.org/10.1186/s12885-017-3897-x
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Mercogliano, María Florencia; Inurrigarro, Gloria; de Martino, Mara; Venturutti, Leandro; Rivas, Martin Alfredo; et al.; Invasive micropapillary carcinoma of the breast overexpresses MUC4 and is associated with poor outcome to adjuvant trastuzumab in HER2-positive breast cancer; BioMed Central; BMC Cancer; 17; 1; 12-2017; 895-895
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