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dc.contributor.author
Santucci, Luca
dc.contributor.author
Fiorucci, Stefano
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Rubinstein, Natalia
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Mencarelli, Andrea
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Pallazzeti, Barbara
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Federici, Barbara
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Rabinovich, Gabriel Adrián
dc.contributor.author
Morelli, Antonio
dc.date.available
2018-02-11T22:32:51Z
dc.date.issued
2003-05
dc.identifier.citation
Santucci, Luca; Fiorucci, Stefano; Rubinstein, Natalia; Mencarelli, Andrea; Pallazzeti, Barbara; et al.; Galectin-1 suppresses experimental colitis in mice; American Gastroenterological Association; Gastroenterology; 124; 5; 5-2003; 1381-1394
dc.identifier.issn
0016-5085
dc.identifier.uri
http://hdl.handle.net/11336/36410
dc.description.abstract
Uncontrolled T-cell activation plays a critical role in the pathogenesis of inflammatory bowel diseases. Therefore, pharmacologic strategies directed to restore the normal responsiveness of the immune system by deleting inappropriately activated T cells could be efficacious in the treatment of these pathologic conditions. Galectin-1 is an endogenous lectin expressed in lymphoid organs that plays a role in the maintenance of central and peripheral tolerance. The aim of the present study was to evaluate the therapeutic effects of galectin-1 on T-helper cell type 1-mediated experimental colitis induced by intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Gastroenterological Association
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Autoimmune Colitis
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Galectin-1
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Tumor Necrosis Factor Alpha
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Human Recombinant Galectin
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Irritable Bowel Disease
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Otras Ciencias Médicas
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Otras Ciencias Médicas
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CIENCIAS MÉDICAS Y DE LA SALUD
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Otras Ciencias Médicas
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Galectin-1 suppresses experimental colitis in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-28T17:49:38Z
dc.journal.volume
124
dc.journal.number
5
dc.journal.pagination
1381-1394
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Bethesda
dc.description.fil
Fil: Santucci, Luca. Università di Perugia; Italia
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Fil: Fiorucci, Stefano. Università di Perugia; Italia
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Fil: Rubinstein, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
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Fil: Mencarelli, Andrea. Università di Perugia; Italia
dc.description.fil
Fil: Pallazzeti, Barbara. Università di Perugia; Italia
dc.description.fil
Fil: Federici, Barbara. Università di Perugia; Italia
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Morelli, Antonio. Università di Perugia; Italia
dc.journal.title
Gastroenterology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0016508503002671
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/S0016-5085(03)00267-1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/12730878
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