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dc.contributor.author
Vanzulli, Silvia
dc.contributor.author
Soldati, Rocío
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Meiss, Roberto
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Colombo, Lucas Luis
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Molinolo, Alfredo
dc.contributor.author
Lanari, Claudia Lee Malvina
dc.date.available
2018-02-11T22:18:50Z
dc.date.issued
2005-03-17
dc.identifier.citation
Vanzulli, Silvia; Soldati, Rocío; Meiss, Roberto; Colombo, Lucas Luis; Molinolo, Alfredo; et al.; Estrogen or antiprogestin treatment induces complete regression of pulmonary and axillary metastases in an experimental model of breast cancer progression; Oxford University Press; Carcinogenesis; 26; 6; 17-3-2005; 1055-1063
dc.identifier.issn
0143-3334
dc.identifier.uri
http://hdl.handle.net/11336/36402
dc.description.abstract
In this paper we demonstrate, using the C7-2-HI metastatic transplantable ductal mammary tumor, that endocrine therapy can induce complete regression of spontaneous lymph node and lung metastases in a mouse model of breast cancer progression. This tumor expresses high levels of estrogen and progesterone receptors and shows a high incidence of early axillary lymph nodes and lung metastases; using this model we had previously shown complete tumor regression of subcutaneous implants. Interestingly, although the metastases showed a more differentiated histology as compared with the primary growth, they underwent complete regression when treated with estrogens or antiprogestins. This phenomenon was associated with sustained cytostasis and apoptosis accompanied by increases in p21 and p27 expression and early tissue remodeling. These results highlight the essential role of PR in regulating cell proliferation in this model as well as its possible use as therapeutic target.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mammary Carcinomas
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Metastasis
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Antiprogestins
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Treatment
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Estrogen or antiprogestin treatment induces complete regression of pulmonary and axillary metastases in an experimental model of breast cancer progression
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-28T17:49:58Z
dc.journal.volume
26
dc.journal.number
6
dc.journal.pagination
1055-1063
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Vanzulli, Silvia. Academia Nacional de Medicina de Buenos Aires; Argentina
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Fil: Soldati, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
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Fil: Meiss, Roberto. Academia Nacional de Medicina de Buenos Aires; Argentina
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Fil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina
dc.description.fil
Fil: Molinolo, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Public Health Service. National Institute Of Health; Estados Unidos
dc.description.fil
Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title
Carcinogenesis
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/carcin/article/26/6/1055/2390876
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/carcin/bgi060
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/15774491
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