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dc.contributor.author
Frungieri, Monica Beatriz
dc.contributor.author
Mayerhofer, Artur
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Zitta, Karina
dc.contributor.author
Pignataro, Omar Pedro
dc.contributor.author
Calandra, Ricardo Saul
dc.contributor.author
Gonzalez Calvar, Silvia I.
dc.date.available
2018-02-11T21:57:59Z
dc.date.issued
2005-03-01
dc.identifier.citation
Frungieri, Monica Beatriz; Mayerhofer, Artur; Zitta, Karina; Pignataro, Omar Pedro; Calandra, Ricardo Saul; et al.; Direct effect of melatonin on Syrian Hamster testes: Mel1a receptors, inhibition on androgen production, and interaction with the local corticotropin-releasing hormone (CRH) system; Endocrine Society; Endocrinology; 146; 3; 1-3-2005; 1541-1552
dc.identifier.issn
0013-7227
dc.identifier.uri
http://hdl.handle.net/11336/36401
dc.description.abstract
Besides the hypothalamus and pituitary, melatonin action at the testicular level has been recently suggested. Therefore, we investigated in the Syrian hamster, a well-characterized seasonal breeder, melatonin action on Leydig cells, testicular expression of melatonergic receptors, and possible interactions between melatonin receptors and the previously identified testicular serotoninergic and CRH systems. In isolated Leydig cells from active testes of adult hamsters kept in a long-day (14 h light, 10 h dark) photoperiod and from regressed testes of adult animals exposed to a short-day photoperiod during 16 wk (6 h light, 18 h dark), melatonin significantly reduced human chorionic gonadotropin-stimulated production of cAMP and the main androgens: testosterone and androstane-3alpha,17beta-diol, respectively, and decreased the expression of steroidogenic acute regulatory protein, P450 side chain cleavage, 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase. In Leydig cells exposed to a short-day photoperiod during 16 wk, melatonin stimulated the conversion of testosterone into 5alpha-reduced androgens by inducing 5alpha-reductase isoform 1, and controlled androstane-3alpha,17beta-diol production by inhibiting 3alpha-hydroxysteroid dehydrogenase expression. Melatonin subtype (mel1a) receptors were detected in Leydig cells. Although the local serotonin system did not mediate melatonin action on androgen production, melatonergic effect on steroidogenesis involved the interaction between mel1a receptors and the inhibitory CRH system. Moreover, melatonin significantly increased CRH mRNA levels and production in hamster Leydig cells expressing CRH subtype 1 receptors. Our studies indicate that melatonin may act as a local inhibitor of human chorionic gonadotropin-stimulated cAMP and androgen production through mel1a receptors, down-regulation of steroidogenic acute regulatory protein, and key steroidogenic enzymes expression and its interaction with the local CRH system.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Endocrine Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Melatonin
dc.subject
Syrian Hamsters
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Leydig Cells
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Testicular Tissue
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Biología Reproductiva
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Direct effect of melatonin on Syrian Hamster testes: Mel1a receptors, inhibition on androgen production, and interaction with the local corticotropin-releasing hormone (CRH) system
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-28T17:49:50Z
dc.identifier.eissn
1945-7170
dc.journal.volume
146
dc.journal.number
3
dc.journal.pagination
1541-1552
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Ludwig Maximilians Universitat; Alemania. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Mayerhofer, Artur. Ludwig Maximilians Universitat; Alemania
dc.description.fil
Fil: Zitta, Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Pignataro, Omar Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Gonzalez Calvar, Silvia I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.journal.title
Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article/146/3/1541/2501167
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/10.1210/en.2004-0990
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/15550508
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