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dc.contributor.author
Schattner, Mirta Ana
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dc.date.available
2018-02-09T17:32:27Z
dc.date.issued
2014-09
dc.identifier.citation
Schattner, Mirta Ana; Platelets and galectins; AME Publishing Company; Annals of Translational Medicine; 2; 9; 9-2014; 85-91
dc.identifier.issn
2305-5839
dc.identifier.uri
http://hdl.handle.net/11336/36318
dc.description.abstract
A major function of platelets is keeping the vascular system intact. Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug. Activation of platelets is therefore crucial for normal hemostasis; however, uncontrolled platelet activation may also lead to the formation of occlusive thrombi that can cause ischemic events. Although they are essential for proper hemostasis, platelet function extends to physiologic processes such as tissue repair, wound remodeling and antimicrobial host defense, or pathologic conditions such as thrombosis, atherosclerosis, chronic inflammatory diseases and cancer. Platelets can be activated by soluble molecules including thrombin, thromboxane A2 (TXA2), adenosine diphosphate (ADP), serotonin or by adhesive extracellular matrix (ECM) proteins such as von Willebrand factor (vWF) and collagen. Here we describe recent advances in the activation of platelets by non-canonical platelet agonists such as galectins. By acting either in soluble or immobilized form, these glycan-binding proteins trigger all platelet activation responses through modulation of discrete signaling pathways. We also offer new hypotheses and some speculations about the role of platelet-galectin interactions not only in hemostasis and thrombosis but also in inflammation and related diseases such as atherosclerosis and cancer.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
AME Publishing Company
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Galectins
dc.subject
Thrombosis
dc.subject
Platelets
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Platelets and galectins
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-02-08T21:12:15Z
dc.journal.volume
2
dc.journal.number
9
dc.journal.pagination
85-91
dc.journal.pais
China
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dc.journal.ciudad
Hong Kong
dc.description.fil
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Annals of Translational Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3978/j.issn.2305-5839.2014.09.02
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://atm.amegroups.com/article/view/4798/5691
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