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dc.contributor.author
Freitag, Nancy
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dc.contributor.author
Zwier, M. V.
dc.contributor.author
Barrientos, Gabriela Laura
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dc.contributor.author
Tirado González, Irene
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dc.contributor.author
Conrad, Melanie L.
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dc.contributor.author
Rose, Matthias
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dc.contributor.author
Scherjon, S. A.
dc.contributor.author
Plösch, T.
dc.contributor.author
Blois, Sandra M.
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dc.date.available
2018-02-08T15:08:34Z
dc.date.issued
2014-08
dc.identifier.citation
Freitag, Nancy; Zwier, M. V.; Barrientos, Gabriela Laura; Tirado González, Irene; Conrad, Melanie L.; et al.; Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring; Nature Publishing Group; Cell Death and Disease; 5; 8-2014; 1-8; e1392
dc.identifier.uri
http://hdl.handle.net/11336/36119
dc.description.abstract
Normal placentation relies on an efficient maternal adaptation to pregnancy. Within the decidua, natural killer (NK) cells and dendritic cells (DC) have a critical role in modulating angiogenesis and decidualization associated with pregnancy. However, the contribution of these immune cells to the placentation process and subsequently fetal development remains largely elusive. Using two different mouse models, we here show that optimal placentation and fetal development is sensitive to disturbances in NK cell relative abundance at the fetal–maternal interface. Depletion of NK cells during early gestation compromises the placentation process by causing alteration in placental function and structure. Embryos derived from NK-depleted dams suffer from intrauterine growth restriction (IUGR), a phenomenon that continued to be evident in the offspring on post-natal day 4. Further, we demonstrate that IUGR was accompanied by an overall reduction of global DNA methylation levels and epigenetic changes in the methylation of specific hepatic gene promoters. Thus, temporary changes within the NK cell pool during early gestation influence placental development and function, subsequently affecting hepatic gene methylation and fetal metabolism.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nk Cells
dc.subject
Dendritic Cells
dc.subject
Placenta
dc.subject
Epigenetics
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Influence of relative NK-DC abundance on placentation and its relation to epigenetic programming in the offspring
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-02-07T20:34:05Z
dc.identifier.eissn
2041-4889
dc.journal.volume
5
dc.journal.pagination
1-8; e1392
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Freitag, Nancy. Medicine University of Berlin; Alemania
dc.description.fil
Fil: Zwier, M. V.. University of Groningen; Países Bajos
dc.description.fil
Fil: Barrientos, Gabriela Laura. Medicine University of Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Tirado González, Irene. Medicine University of Berlin; Alemania
dc.description.fil
Fil: Conrad, Melanie L.. Medicine University of Berlin; Alemania
dc.description.fil
Fil: Rose, Matthias. Medicine University of Berlin; Alemania
dc.description.fil
Fil: Scherjon, S. A.. University of Groningen; Países Bajos
dc.description.fil
Fil: Plösch, T.. University of Groningen; Países Bajos
dc.description.fil
Fil: Blois, Sandra M.. Medicine University of Berlin; Alemania
dc.journal.title
Cell Death and Disease
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/cddis.2014.353
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/cddis2014353
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25165878/
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