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dc.contributor.author
Vasti, Cecilia
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dc.contributor.author
Hertig, Cecilia Margarita
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dc.date.available
2018-02-08T14:47:58Z
dc.date.issued
2014-07
dc.identifier.citation
Vasti, Cecilia; Hertig, Cecilia Margarita; Neuregulin-1/erbB activities with focus on the susceptibility of the heart to anthracyclines; Baishideng Publishing Group; World Journal of Cardiology; 6; 7; 7-2014; 653-662
dc.identifier.issn
1949-8462
dc.identifier.uri
http://hdl.handle.net/11336/36100
dc.description.abstract
Neuregulin-1 (NRG1) signaling through the tyrosine kinase receptors erbB2 and erbB4 is required for cardiac morphogenesis, and it plays an essential role in maintaining the myocardial architecture during adulthood. The tyrosine kinase receptor erbB2 was first linked to the amplification and overexpression of erbb2 gene in a subtype of breast tumor cells, which is indicative of highly proliferative cells and likely a poor prognosis following conventional chemotherapy. The development of targeted therapies to block the survival of erbB2-positive cancer cells revealed that impaired NRG1 signaling through erbB2/erbB4 heterodimers combined with anthracycline chemotherapy may lead to dilated cardiomyopathy in a subpopulation of treated patients. The ventricular-specific deletion of either erbb2 or erbb4 manifested dilated cardiomyopathy, which is aggravated by the administration of doxorubicin. Based on the exacerbated toxicity displayed by the combined treatment, it is expected that the relevant pathways would be affected in a synergistic manner. This review examines the NRG1 activities that were monitored in different model systems, focusing on the emerging pathways and molecular targets, which may aid in understanding the acquired dilated cardiomyopathy that occurs under the conditions of NRG1-deficient signaling.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Baishideng Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ventricular Dilation
dc.subject
Cardiotoxicity
dc.subject
Erbb2
dc.subject
Erbb4
dc.subject
Neuregulin
dc.subject
Trastuzumab
dc.subject
Doxorubicin
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Neuregulin-1/erbB activities with focus on the susceptibility of the heart to anthracyclines
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-02-07T20:36:45Z
dc.journal.volume
6
dc.journal.number
7
dc.journal.pagination
653-662
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Pleasanton
dc.description.fil
Fil: Vasti, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Hertig, Cecilia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.journal.title
World Journal of Cardiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1949-8462/full/v6/i7/653.htm
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4330/wjc.v6.i7.653
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