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dc.contributor.author
Daroqui, Maria Cecilia  
dc.contributor.author
Puricelli, Lydia Ines  
dc.contributor.author
Urtreger, Alejandro Jorge  
dc.contributor.author
Bal de Kier Joffe, Elisa  
dc.contributor.author
Elizalde, Patricia Virginia  
dc.contributor.author
Lanuza, Guillermo Marcos  
dc.date.available
2018-02-08T13:45:05Z  
dc.date.issued
2003-08  
dc.identifier.citation
Daroqui, Maria Cecilia; Puricelli, Lydia Ines; Urtreger, Alejandro Jorge; Bal de Kier Joffe, Elisa; Elizalde, Patricia Virginia; et al.; Involvement of TGF-βs/TβRs System in Tumor Progression of Murine Mammary Adenocarcinomas; Springer; Breast Cancer Research and Treatment; 80; 3; 8-2003; 287-301  
dc.identifier.issn
0167-6806  
dc.identifier.uri
http://hdl.handle.net/11336/36094  
dc.description.abstract
We studied the expression of TGF-beta/T(beta)R system and its biological role in tumor development, in M3 and MM3 murine mammary adenocarcinomas with different metastasizing capability and in LM3 and LMM3 derived cell lines. All the studied cells secreted TGF-beta(s) and expressed T(beta)Rs. While the proliferation of the poorly metastatic M3 cells was significantly inhibited by 4 ng/ml TGF-beta(s), the highly metastatic MM3 cells were only slightly inhibited in response to the highest dose used. LM3 and LMM3 cells, highly invasive and metastatic, were totally refractory to TGF-beta antiproliferative effect. The role of TGF-beta in modulating key proteolytic cascades in tumor progression was also studied. TGF-beta(s) enhanced metalloproteinases production in all the studied cells while induced a stimulatory net effect on plasmin system activity only in the more metastatic cells. Our results in this murine mammary tumor lineage support the concept that dissociation of TGF-beta regulated growth control versus proteolytic enzyme pathways promotes tumor dissemination.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Egf- Beta  
dc.subject
Mmp  
dc.subject
Murine Mammary Adenocarcinoma  
dc.subject.classification
Patología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Involvement of TGF-βs/TβRs System in Tumor Progression of Murine Mammary Adenocarcinomas  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-12-28T13:40:39Z  
dc.identifier.eissn
1573-7217  
dc.journal.volume
80  
dc.journal.number
3  
dc.journal.pagination
287-301  
dc.journal.pais
Alemania  
dc.journal.ciudad
Berlin  
dc.description.fil
Fil: Daroqui, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Puricelli, Lydia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Urtreger, Alejandro Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Bal de Kier Joffe, Elisa. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Elizalde, Patricia Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.description.fil
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.journal.title
Breast Cancer Research and Treatment  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1023/A:1024910332621  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1023/A:1024910332621