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dc.contributor.author Daroqui, Maria Cecilia
dc.contributor.author Puricelli, Lydia Ines
dc.contributor.author Urtreger, Alejandro Jorge
dc.contributor.author Bal de Kier Joffe, Elisa
dc.contributor.author Elizalde, Patricia Virginia
dc.contributor.author Lanuza, Guillermo Marcos
dc.date.available 2018-02-08T13:45:05Z
dc.date.issued 2003-08
dc.identifier.citation Daroqui, Maria Cecilia; Puricelli, Lydia Ines; Urtreger, Alejandro Jorge; Bal de Kier Joffe, Elisa; Elizalde, Patricia Virginia; et al.; Involvement of TGF-beta(s)/T(beta)Rs system in tumor progression of murine mammary adenocarcinomas; Springer; Breast Cancer Research and Treatment; 80; 3; 8-2003; 287-301
dc.identifier.issn 0167-6806
dc.identifier.uri http://hdl.handle.net/11336/36094
dc.description.abstract We studied the expression of TGF-beta/T(beta)R system and its biological role in tumor development, in M3 and MM3 murine mammary adenocarcinomas with different metastasizing capability and in LM3 and LMM3 derived cell lines. All the studied cells secreted TGF-beta(s) and expressed T(beta)Rs. While the proliferation of the poorly metastatic M3 cells was significantly inhibited by 4 ng/ml TGF-beta(s), the highly metastatic MM3 cells were only slightly inhibited in response to the highest dose used. LM3 and LMM3 cells, highly invasive and metastatic, were totally refractory to TGF-beta antiproliferative effect. The role of TGF-beta in modulating key proteolytic cascades in tumor progression was also studied. TGF-beta(s) enhanced metalloproteinases production in all the studied cells while induced a stimulatory net effect on plasmin system activity only in the more metastatic cells. Our results in this murine mammary tumor lineage support the concept that dissociation of TGF-beta regulated growth control versus proteolytic enzyme pathways promotes tumor dissemination.
dc.format application/pdf
dc.language.iso eng
dc.publisher Springer
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject EGF- beta
dc.subject MMP
dc.subject MURINE MAMMARY ADENOCARCINOMA
dc.subject.classification Patología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Involvement of TGF-beta(s)/T(beta)Rs system in tumor progression of murine mammary adenocarcinomas
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-12-28T13:40:39Z
dc.identifier.eissn 1573-7217
dc.journal.volume 80
dc.journal.number 3
dc.journal.pagination 287-301
dc.journal.pais Alemania
dc.journal.ciudad Berlin
dc.description.fil Fil: Daroqui, Maria Cecilia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina
dc.description.fil Fil: Puricelli, Lydia Ines. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina
dc.description.fil Fil: Urtreger, Alejandro Jorge. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina
dc.description.fil Fil: Bal de Kier Joffe, Elisa. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina
dc.description.fil Fil: Elizalde, Patricia Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title Breast Cancer Research and Treatment
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1023/A:1024910332621
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/pmid/14503801
dc.conicet.fuente individual


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    Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)