Artículo
Ileal Ganglioneuromatosis in a Piglet: Histopathological and Immunohistochemical Studies
Quiroga, María Alejandra; Lozada, María Inés
; Madariaga, Gonzalo Julián; Cappuccio, Javier Alejandro
; Machuca, Mariana Alejandra; Barrales, H.; Pérez, Estefanía Marisol
; Perfumo, C. J.
Fecha de publicación:
09/2014
Editorial:
Elsevier
Revista:
Journal Of Comparative Pathology
ISSN:
0021-9975
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Ganglioneuromatosis (GNM) is a rare condition characterized by the benign proliferation of ganglion cells, nerve fibres and supporting cells of the enteric nervous system. Necropsy examination of a female piglet weighing 4 kg revealed a well-demarcated 20 cm segment of terminal ileum with thickening of the wall. Microscopically, the lamina propria was infiltrated by enteric glial cells and large ganglion cells. Within the submucosal and muscular layers, aggregates of neurons were interlaced by Schwann cells and enteric glial cells arranged in concentric rings. Immunohistochemically, the neurons were weakly labelled for S-100 and neuron-specific enolase, Schwann cells expressed S-100 and vimentin and enteric glial cells expressed glial fibrillary acidic protein and S-100. Pathological and immunohistochemical findings supported the diagnosis of ileal GNM.
Palabras clave:
Ganglioneuromatosis
,
Histopathology
,
Immunohistochemistry
,
Pig
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Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Quiroga, María Alejandra; Lozada, María Inés; Madariaga, Gonzalo Julián; Cappuccio, Javier Alejandro; Machuca, Mariana Alejandra; et al.; Ileal Ganglioneuromatosis in a Piglet: Histopathological and Immunohistochemical Studies; Elsevier; Journal Of Comparative Pathology; 151; 4; 9-2014; 380-383
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