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Artículo

Microthermodynamic Interpretation of Fluid States from FTIR Measurements in Lipid Membranes: A Monte Carlo Study

Pinto, Oscar AlejandroIcon ; Bouchet, Ana MaríaIcon ; Frías, María de los ÁngelesIcon ; Disalvo, Edgardo AnibalIcon
Fecha de publicación: 08/2014
Editorial: American Chemical Society
Revista: Journal of Physical Chemistry B
ISSN: 1089-5647
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Fourier transform infrared spectroscopy (FTIR) is usually employed to obtain transition temperatures of lipids and lipid mixtures and the effect on it of several effectors, such as cholesterol. However, no interpretation of the molecular information provided by the frequency shift to higher values observed at Tc is available. In this article, we demonstrate that data obtained by means of FTIR measurements contain information about the microscopic thermodynamics of the lipid-phase transition. By means of Monte Carlo simulation, we have been able to show that the frequency shift from low to high values can be taken as a two-state transition of molecular constituents in a lattice rearrangement. According to the model, at temperatures below Tc all of the groups are defined in the lowest-energy state defined by the lowest frequency value and therefore they are all connected in a gel lattice. Above Tc, some groups may reach different energy states depending on the restrictions imposed on the groups. Ideally, when all of the groups are able to reach the highest frequency, a fully “fluid” state is reached, which is a disordered state. If we take this hypothetical state as a reference, it is possible to show that the higher states become less accessible. The model is suitable for describing the effect of cholesterol, which is able to dump the phase transition and is congruent with previous data denoting that in the so-called fluid phase the first four to five methylene groups remain in the gel state even above Tc. The frequency value attained above Tc depends on the nature of the lipid acyl chain.
Palabras clave: Methylene Groups , Ftir , Lipid Membranes , Asymmetric Frequency Shift
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/35908
DOI: http://dx.doi.org/10.1021/jp5044078
URL: https://pubs.acs.org/doi/10.1021/jp5044078
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Pinto, Oscar Alejandro; Bouchet, Ana María; Frías, María de los Ángeles; Disalvo, Edgardo Anibal; Microthermodynamic Interpretation of Fluid States from FTIR Measurements in Lipid Membranes: A Monte Carlo Study; American Chemical Society; Journal of Physical Chemistry B; 118; 35; 8-2014; 10436-10443
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