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dc.contributor.author
Astort, Francisco
dc.contributor.author
Sittner, Maximiliano
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Ferraro, Sebastián Ariel
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Orona, Nadia Soledad
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Maglione, Guillermo Alberto
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Perez de la Hoz, A.
dc.contributor.author
Tasat, Deborah Ruth
dc.date.available
2018-02-06T20:37:32Z
dc.date.issued
2014-07
dc.identifier.citation
Astort, Francisco; Sittner, Maximiliano; Ferraro, Sebastián Ariel; Orona, Nadia Soledad; Maglione, Guillermo Alberto; et al.; Pulmonary inflammation and cell death in mice after acute exposure to air particulate matter from an industrial region of Buenos Aires.; Springer; Archives of Environmental Contamination and Toxicology; 67; 1; 7-2014; 87-96
dc.identifier.issn
0090-4341
dc.identifier.uri
http://hdl.handle.net/11336/35892
dc.description.abstract
Epidemiological studies have shown that air particulate matter (PM) can increase respiratory morbidity and mortality being the lungs the main target organ to PM body entrance. Even more, several in vivo and in vitro studies have shown that air PM has a wide toxicity spectra depending among other parameters, on its size, morphology, and chemical composition. The Reconquista River is the second most polluted river from Buenos Aires, and people living around its basin are constantly exposed to its contaminated water, soil and air. However, the air PM from the Reconquista River (RR-PMa) has not been characterized, and its biological impact on lung has yet not been assessed. Therefore, the present investigation was undertaken to study (1) RR-PMa morphochemical characteristic and (2) RR-PMa lung acute effects after intranasal instillation exposure through the analysis of three end points: oxidative stress, inflammation, and apoptosis. A single acute exposure of RR-PMa (1 mg/kg body weight) after 24 h caused significant (p < 0.05) enrichment in bronchoalveolar total cell number and polymorphonuclear (PNM) fraction, superoxide anion generation, production of pro-inflammatory cytokines TNF-α and IL-6, and induction of apoptosis. It was also observed that in lung homogenates, none of the antioxidant enzymes assayed showed differences between exposed RR-PMa and control mice. These data demonstrate that air PM from the Reconquista River induce lung oxidative stress, inflammation, and cell death therefore represents a potential hazard to human health.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Total Cell Number
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Ultrafine Particle
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Superoxide Anion Generation
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Lung Homogenate
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Keratoconjunctivitis Sicca
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Pulmonary inflammation and cell death in mice after acute exposure to air particulate matter from an industrial region of Buenos Aires.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-02-06T20:09:29Z
dc.journal.volume
67
dc.journal.number
1
dc.journal.pagination
87-96
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Astort, Francisco. Universidad Nacional de San Martín; Argentina
dc.description.fil
Fil: Sittner, Maximiliano. Universidad Nacional de San Martín; Argentina
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Fil: Ferraro, Sebastián Ariel. Universidad Nacional de San Martín; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
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Fil: Orona, Nadia Soledad. Universidad Nacional de San Martín; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
dc.description.fil
Fil: Maglione, Guillermo Alberto. Universidad Nacional de San Martín; Argentina
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Fil: Perez de la Hoz, A.. Universidad Nacional de San Martín; Argentina
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Fil: Tasat, Deborah Ruth. Universidad Nacional de San Martín; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.journal.title
Archives of Environmental Contamination and Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00244-013-9975-4
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00244-013-9975-4
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