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dc.contributor.author
Pedrana, G.
dc.contributor.author
Viotti, M. H.
dc.contributor.author
Souza, E.
dc.contributor.author
Slodoba, D.
dc.contributor.author
Martin, G. B.
dc.contributor.author
Cavestany, D.
dc.contributor.author
Ortega, Hugo Hector
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dc.date.available
2016-01-13T18:14:55Z
dc.date.issued
2013-05
dc.identifier.citation
Pedrana, G.; Viotti, M. H.; Souza, E.; Slodoba, D.; Martin, G. B.; et al.; Apoptosis-Related Protein Expression During Pre- and Post-Natal Testicular Development After Administration of Glucocorticoid in utero in the Sheep; Wiley; Reproduction in Domestic Animals; 48; 5; 5-2013; 795-802
dc.identifier.issn
0936-6768
dc.identifier.uri
http://hdl.handle.net/11336/3586
dc.description.abstract
Pre-natal glucocorticoids are used in women at risk of preterm delivery to induce foetal lung maturation. However, glucocorticoids can produce negative outcomes for other tissues such as the reproductive system. We therefore tested the effects of pre-natal betamethasone on testicular morphology and apoptotic protein immune expression during pre- and post-natal development. Pregnant ewes (n = 42) bearing singleton male foetuses were randomly allocated to receive intramuscular injections of saline or betamethasone (0. 5 mg/kg) at 104, 111 and 118 days of gestation (DG). Testes were collected at 121 and 132 DG, and at 45 and 90 post-natal days (PD) and subjected to morphometric analysis (volume densities of sex cords and interstitial tissues; sex cord diameter). Immunohistochemistry (% stained area) was used to assess active caspase-3, Bax, Bcl-2 and cell-cycle proteins (PCNA). Compared with control values, betamethasone treatment decreased sex cord diameter at 121 DG, 45 and 90 PD, and sex cord volume at 90 PD. Active caspase-3 was decreased by betamethasone at 121 DG and 90 PD, but Bax was increased in all betamethasone groups. Bcl-2 and PCNA decreased in the betamethasone groups at 121 DG and 45 PD, but increased at 132 DG and 90 PD. We conclude that high levels of pre-natally administered glucocorticoid reduce foetal testicular development, perhaps via changes in the balance between pro- and anti-apoptotic proteins and cell-cycle proteins. These outcomes could compromise the future spermatogenic potential of male offspring.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ovario
dc.subject
Pubertar
dc.subject
Cortisol
dc.subject
Ovejas
dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Apoptosis-Related Protein Expression During Pre- and Post-Natal Testicular Development After Administration of Glucocorticoid in utero in the Sheep
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
48
dc.journal.number
5
dc.journal.pagination
795-802
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Pedrana, G.. Universidad de la Republica; Uruguay
dc.description.fil
Fil: Viotti, M. H.. Universidad de la Republica; Uruguay
dc.description.fil
Fil: Souza, E.. Universidad de la Republica; Uruguay
dc.description.fil
Fil: Slodoba, D.. Mc Master University; Canadá
dc.description.fil
Fil: Martin, G. B.. University of Western Australia; Australia
dc.description.fil
Fil: Cavestany, D.. Universidad de la Republica; Uruguay
dc.description.fil
Fil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
dc.journal.title
Reproduction in Domestic Animals
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/rda.12164/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/DOI:10.1111/rda.12164
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/0936-6768
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