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dc.contributor.author
Morcillo, Nora S.
dc.contributor.author
Imperiale, Belén Rocío
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dc.contributor.author
Di Giulio, Angela
dc.contributor.author
Zumárraga, Martín José
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dc.contributor.author
Takiff, Howard
dc.contributor.author
Cataldi, Ángel Adrián
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dc.date.available
2018-02-06T14:22:25Z
dc.date.issued
2014-06
dc.identifier.citation
Morcillo, Nora S.; Imperiale, Belén Rocío; Di Giulio, Angela; Zumárraga, Martín José; Takiff, Howard; et al.; Fitness of drug resistant Mycobacterium tuberculosis and the impact on the transmission among household contacts; Churchill Livingstone; Tuberculosis (Edinb); 94; 6; 6-2014; 672-677
dc.identifier.issn
1472-9792
dc.identifier.uri
http://hdl.handle.net/11336/35740
dc.description.abstract
There has been an on-going debate on whether the development of drug resistance in Mycobacterium tuberculosis reduces its relative fitness and its ability to cause disease. The aim of this study was to explore this relationship. For this purpose, we evaluated the in vitro growth of clinical isolates and the transmission of the strains within the patients' households. Clinical and epidemiological data from patients in households, drug-susceptibility and genetic patterns of the isolates were collected. BACTEC MGIT 960™ system with the Epicenter™ software was used to perform fitness experiments and calculate the relative fitness (RF) comparing with the H73Rv reference strain. From 39 households, 124 patients and 388 contacts were included. Concerning transmission, 20 Multi drug-resistant (MDR) and 16 drug sensitive (DS) index cases generated 23 and 28 secondary cases, respectively. An average RF drop of 16.7% was found for MDR strains, but only mutations in rpoB codons 531 were associated with reduced fitness. When the strains were transmitted, their RF tended to decrease, and strains with low RF were less frequently transmitted. Within the limitations of this study, the results showed that the decrease in RF was associated to a limited transmission among the households' contacts.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Churchill Livingstone
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Drug-Resistance
dc.subject
Tuberculosis
dc.subject
Fitness
dc.subject
Household Contacts
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Family Transmission
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Fitness of drug resistant Mycobacterium tuberculosis and the impact on the transmission among household contacts
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-02-05T20:22:27Z
dc.journal.volume
94
dc.journal.number
6
dc.journal.pagination
672-677
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Edinburgh
dc.description.fil
Fil: Morcillo, Nora S.. Provincia de Buenos Aires. Ministerio de Salud. Hospital "Dr. Antonio A. Cetrángolo"; Argentina
dc.description.fil
Fil: Imperiale, Belén Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Ministerio de Salud. Hospital "Dr. Antonio A. Cetrángolo"; Argentina
dc.description.fil
Fil: Di Giulio, Angela. Hospital Petrona V. de Cordero. San Fernando; Argentina
dc.description.fil
Fil: Zumárraga, Martín José. Instituto Nacional de Tecnología Agropecuaria; Argentina
dc.description.fil
Fil: Takiff, Howard. Instituto Venezolano de Investigaciones Científicas; Venezuela
dc.description.fil
Fil: Cataldi, Ángel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria; Argentina
dc.journal.title
Tuberculosis (Edinb)
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1472979214203908
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.tube.2014.08.003
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