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dc.contributor.author
Abraham, Gustavo Abel
dc.contributor.author
De Queiroz, Alvaro A.A.
dc.contributor.author
San Roman, Julio
dc.date.available
2018-02-06T14:16:13Z
dc.date.issued
2001-06-18
dc.identifier.citation
Abraham, Gustavo Abel; De Queiroz, Alvaro A.A.; San Roman, Julio; Hydrophilic hybrid IPNs of segmented polyurethanes and copolymers of vinylpyrrolidone for applications in medicine; Elsevier; Biomaterials; 22; 14; 18-6-2001; 1971-1985
dc.identifier.issn
0142-9612
dc.identifier.uri
http://hdl.handle.net/11336/35735
dc.description.abstract
The preparation and biocompatibility properties of thermoplastic apparent interpenetrating polymer networks (T-IPNs) of a segmented polyurethaneurea, Biospan™ (BS), and vinylpyrrolidone–dimethylacrylamide (VP–DMAm) copolymers, are described. The biological interaction between the obtained materials and blood was studied by in vitro methods. The addition of the VP–DMAm copolymers to form T-IPNs with BS substantially increased the equilibrium water uptake and water diffusion coefficients. Investigation of the proteins adsorption, platelet adhesion, thrombus formation and factor XII activation is presented. Investigations of the proteins adsorption of the BS/VP–DMAm T-IPNs surfaces show that the segmented polyurethane (BS) containing VP–DMAm copolymers with higher VP content adsorb more albumin than fibrinogen and γ-globulin. The platelets adhesion, thrombus formation and factor XII activation are effectively suppressed with respect to the segmented polyurethane when VP–DMAm copolymers with high VP contents are incorporated into BS as T-IPNs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
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Otras Biotecnologías de la Salud
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Biotecnología de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Hydrophilic hybrid IPNs of segmented polyurethanes and copolymers of vinylpyrrolidone for applications in medicine
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-02-02T19:44:27Z
dc.journal.volume
22
dc.journal.number
14
dc.journal.pagination
1971-1985
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.description.fil
Fil: De Queiroz, Alvaro A.A.. Universidade Federal de Itajubá; Brasil
dc.description.fil
Fil: San Roman, Julio. Instituto de Ciencia y Tecnolognia de Polimeros; España
dc.journal.title
Biomaterials
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0142961200003811
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/doi.org/10.1016/S0142-9612(00)00381-1
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