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dc.contributor.author
Wentzel, Jolanda J.  
dc.contributor.author
Gijsen, Frank J.H.  
dc.contributor.author
der Giessen, Rosevan  
dc.contributor.author
Rodriguez Granillo, Gaston Alfredo  
dc.contributor.author
Schuurbiers, Johan C.H.  
dc.contributor.author
Regar, E.  
dc.contributor.author
de Feyter, Pim J.  
dc.contributor.author
van der Steenac, Antonius F.W.  
dc.date.available
2018-02-02T14:27:19Z  
dc.date.issued
2014-06  
dc.identifier.citation
Wentzel, Jolanda J.; Gijsen, Frank J.H.; der Giessen, Rosevan; Rodriguez Granillo, Gaston Alfredo; Schuurbiers, Johan C.H.; et al.; Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.; Elsevier Ireland; Atherosclerosis; 236; 1; 6-2014; 82-90  
dc.identifier.issn
0021-9150  
dc.identifier.uri
http://hdl.handle.net/11336/35471  
dc.description.abstract
Aims At present it is unknown what limits the arterial remodeling process during atherosclerotic plaque formation. In healthy arteries remodeling is regulated by the shear stress induced response by the endothelium. As endothelium at the plaque site is assumed to be dysfunctional, we tested the hypothesis that plaque free wall (PFW) determines vascular remodeling during atherosclerotic plaque build-up. Methods & results 66 human coronary ROIs (38 patients) were studied at baseline and at 3 years follow up applying intravascular ultrasound (IVUS). From the IVUS images the lumen and external elastic membrane contours were delineated to assess wall thickness (WT), vessel area (VA), Plaque Area (PA) and plaque burden (PA/VA*100%). WT < 0.5 mm was defined as normal and determined the arc of the PFW (0–360°). Positive remodeling was defined as relative difference of VA over time >5%. At baseline, IVUS-PFW was inversely related to plaque burden (p < 0.05). Positive remodeling was most frequently observed in ROIs with IVUS-PFW > 180° (i.e. larger than half of the circumference) compared to PFW < 180° (55% vs. 12%, p < 0.05). Accordingly, plaques with IVUS-PFW > 180° at baseline had the largest change in VA (1.1 ± 2.1 vs. −0.4 ± 0.6 mm2, p < 0.05) with an odds ratio of 9.2 to develop positive remodeling. Conclusions Our serial IVUS data show that IVUS-PFW is a determinant of vascular remodeling. ROIs with PFW > 180 at baseline had the highest probability to undergo positive remodeling.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Ireland  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Remodeling  
dc.subject
Ivus  
dc.subject
Atherosclerosis  
dc.subject.classification
Medicina Critica y de Emergencia  
dc.subject.classification
Medicina Clínica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Positive remodeling at 3 year follow up is associated with plaque free coronary wall segment at baseline: A serial IVUS study.  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-02-02T13:29:10Z  
dc.journal.volume
236  
dc.journal.number
1  
dc.journal.pagination
82-90  
dc.journal.pais
Irlanda  
dc.journal.ciudad
Shannon  
dc.description.fil
Fil: Wentzel, Jolanda J.. ErasmusMC. Rotterdam; Países Bajos. The Interuniversity Cardiology Institute the Netherlands. Utrecht; Países Bajos  
dc.description.fil
Fil: Gijsen, Frank J.H.. ErasmusMC. Rotterdam; Países Bajos  
dc.description.fil
Fil: der Giessen, Rosevan. ErasmusMC. Rotterdam; Países Bajos  
dc.description.fil
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. ErasmusMC. Rotterdam; Países Bajos  
dc.description.fil
Fil: Schuurbiers, Johan C.H.. ErasmusMC. Rotterdam; Países Bajos  
dc.description.fil
Fil: Regar, E.. ErasmusMC. Rotterdam; Países Bajos  
dc.description.fil
Fil: de Feyter, Pim J.. ErasmusMC. Rotterdam; Países Bajos  
dc.description.fil
Fil: van der Steenac, Antonius F.W.. ErasmusMC. Rotterdam; Países Bajos. The Interuniversity Cardiology Institute the Netherlands. Utrecht; Países Bajos  
dc.journal.title
Atherosclerosis  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.atherosclerosis.2014.06.013  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S002191501401243X