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dc.contributor.author
Horak, Cristina Natalia
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dc.contributor.author
Assef, Yanina Andrea
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dc.date.available
2018-01-30T16:00:55Z
dc.date.issued
2017-10-02
dc.identifier.citation
Horak, Cristina Natalia; Assef, Yanina Andrea; Influence of Water Temperature on the MXR Activity and P-glycoprotein Expression in the Freshwater Snail, Physa acuta (Draparnaud, 1805); Academia Sinica; Zoological Studies; 56; 27; 2-10-2017; 1-11
dc.identifier.issn
1021-5506
dc.identifier.uri
http://hdl.handle.net/11336/34998
dc.description.abstract
P-glycoprotein (P-gp) mediated multixenobioticresistance (MXR) is a mechanism analogous to multidrug resistance, which has been extensivelycharacterized in mammalian tumours. The expression and function of the MXR mechanism hasbeen demonstrated in numerous aquatic organisms and has been proposed as a biomarker forpollution assessment. A close relationship between thermal stress and MXR response has beenreported in some aquatic organisms. Seasonal studies in freshwater organisms are scarce andconducted mainly in zebra mussel (Dreissena polymorpha), whose presence has not been reportedin South America. The general purpose of the present study was to evaluate seasonal variation of abiomarker, the MXR mechanism, in the worldwide distributed freshwater snail P. acuta. Weanalyzed the in situ influence of temperature on the biomarker response over an 18-month fieldstudy. MXR defence system was evaluated by a combination of functional assays (RB accumulation)and molecular approaches to analyse P-gp expression. The results demonstrated a linear correlationbetween MXR response, at activity and expression level, and water temperature at sample site, in P.acuta snails. The characterization of the MXR system in worldwide distributed species, includingthe study of their seasonal fluctuations, could contribute to the increasing interest to incorporate thisbiomarker to provide an integrated assessment of mussel health status. This work supports thepossible use of P. acuta snails with this purpose and also highlights that the occurrence of variationsin MXR response related to water temperature has to be taken into account in the interpretation ofin situ monitoring studies
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academia Sinica
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mxr
dc.subject
P-Glycoprotein
dc.subject
Biomarker
dc.subject
Temperature
dc.subject
Freshwater Snail
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Influence of Water Temperature on the MXR Activity and P-glycoprotein Expression in the Freshwater Snail, Physa acuta (Draparnaud, 1805)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-15T14:31:58Z
dc.journal.volume
56
dc.journal.number
27
dc.journal.pagination
1-11
dc.journal.pais
China
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dc.journal.ciudad
Taiwan
dc.description.fil
Fil: Horak, Cristina Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Centro de Investigación Esquel de Montaña y Estepa Patagóica. Universidad Nacional de la Patagonia ; Argentina
dc.description.fil
Fil: Assef, Yanina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Centro de Investigación Esquel de Montaña y Estepa Patagóica. Universidad Nacional de la Patagonia ; Argentina
dc.journal.title
Zoological Studies
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://zoolstud.sinica.edu.tw/Journals/56/56-27.pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.6620/ZS.2017.56- 27
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