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Artículo

Efficacy of Essential Oils of Thymus vulgaris and Origanum vulgare on Echinococcus granulosus

Pensel, Patricia EugeniaIcon ; Maggiore, Marina AlejandraIcon ; Gende, Liesel BrendaIcon ; Eguaras, Martin JavierIcon ; Denegri, Guillermo MariaIcon ; Elissondo, María CelinaIcon
Fecha de publicación: 08/2014
Editorial: Hindawi Publishing Corporation
Revista: Interdisciplinary Perspectives on Infectious Diseases
ISSN: 1687-708X
e-ISSN: 1687-7098
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Farmacología y Farmacia

Resumen

The aim of the present work was to determine the in vitro effect of T. vulgaris and O. vulgare essential oils against E. granulosus protoscoleces and cysts. Essential oils were added to the medium resulting in thymol final concentrations of 10 μg/mL. The essential oils had a time-dependent effect provoking the complete loss of protoscolex viability after 72 days of postincubation. The results were confirmed at the ultrastructure level. Loss of infectivity in protoscoleces incubated with O. vulgare after 60 days was observed. On the other hand, the weight of cysts recorded in mice inoculated with T. vulgaris treated protoscoleces was significantly lower than that obtained in control group. Gamma-glutamyl-transpeptidase activity was readily detected in the culture supernatant of protoscoleces treated either with the essential oils or thymol. T. vulgaris and O. vulgare essential oils and thymol can induce cell apoptosis of protoscoleces after short incubation times. The efficacy of T. vulgaris and O. vulgare essential oils was also demonstrated in vitro on E. granulosus murine cysts. Our data suggest that essential oils of T. vulgaris and O. vulgare have anthelmintic effect against protoscoleces and cysts of E. granulosus.
Palabras clave: Echinococcus Granulosus , Cystic Echinococcosis , Essential Oils , Thymus Vulgaris , Origanum Vulgare , Thymol
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/34896
DOI: http://dx.doi.org/10.1155/2014/693289
URL: https://www.hindawi.com/journals/ipid/2014/693289/
Colecciones
Articulos(CCT - MAR DEL PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - MAR DEL PLATA
Citación
Pensel, Patricia Eugenia; Maggiore, Marina Alejandra; Gende, Liesel Brenda; Eguaras, Martin Javier; Denegri, Guillermo Maria; et al.; Efficacy of Essential Oils of Thymus vulgaris and Origanum vulgare on Echinococcus granulosus; Hindawi Publishing Corporation; Interdisciplinary Perspectives on Infectious Diseases; 2014; 8-2014; 1-12
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