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dc.contributor.author
Malbrán, Alejandro
dc.contributor.author
Riedl, M.
dc.contributor.author
Ritchie, B.
dc.contributor.author
Smith, W. B.
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Yang, W.
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Banerji, A.
dc.contributor.author
Hébert, J.
dc.contributor.author
Gleich, G. J.
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Hurewitz, D.
dc.contributor.author
Jacobson, K. W.
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Bernstein, J. A.
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Khan, D. A.
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Kirkpatrick, C. H.
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Resnick, D.
dc.contributor.author
Li, H.
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Fernández Romero, D. S.
dc.contributor.author
Lum, W.
dc.date.available
2018-01-23T18:21:31Z
dc.date.issued
2014-07
dc.identifier.citation
Malbrán, Alejandro; Riedl, M.; Ritchie, B.; Smith, W. B.; Yang, W.; et al.; Repeat treatment of acute hereditary angioedema attacks with open-label icatibant in the FAST-1 trial; Wiley; Clinical and Experimental Immunology; 177; 2; 7-2014; 544-553
dc.identifier.issn
0009-9104
dc.identifier.uri
http://hdl.handle.net/11336/34301
dc.description.abstract
Hereditary angioedema (HAE) is characterized by potentially lifethreatening recurrent episodes of oedema. The open-label extension (OLE) phase of the For Angioedema Subcutaneous Treatment (FAST)-1 trial (NCT00097695) evaluated the efficacy and safety of repeated icatibant exposure in adults with multiple HAE attacks. Following completion of the randomized, controlled phase, patients could receive open-label icatibant (30 mg subcutaneously) for subsequent attacks. The primary end-point was time to onset of primary symptom relief, as assessed by visual analogue scale (VAS). Descriptive statistics were reported for cutaneous/abdominal attacks 1–10 treated in the OLE phase and individual laryngeal attacks. Post-hoc analyses were conducted in patients with ≥ 5 attacks across the controlled and OLE phases. Safety was evaluated throughout. During the OLE phase, 72 patients received icatibant for 340 attacks. For cutaneous/abdominal attacks 1–10, the median time to onset of primary symptom relief was 1·0–2·0 h. For laryngeal attacks 1–12, patient-assessed median time to initial symptom improvement was 0·3–1·2 h. Post-hoc analyses showed the time to onset of symptom relief based on composite VAS was consistent across repeated treatments with icatibant. One injection of icatibant was sufficient to treat 88·2% of attacks; rescue medication was required in 5·3% of attacks. No icatibantrelated serious adverse events were reported. Icatibant provided consistent efficacy and was well tolerated for repeated treatment of HAE attacks.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bradykinin B2 Receptor Antagonist
dc.subject
C1-Inhibitor Deficiency
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Fast-1
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Hereditary Angioedema
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Icatibant
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Ole Phase
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Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Repeat treatment of acute hereditary angioedema attacks with open-label icatibant in the FAST-1 trial
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-23T17:20:42Z
dc.identifier.eissn
1365-2249
dc.journal.volume
177
dc.journal.number
2
dc.journal.pagination
544-553
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Malbrán, Alejandro. Hospital Británico de Buenos Aires. Servicio de Alergia e Inmunología Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Riedl, M.. University of California at Los Angeles; Estados Unidos
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Fil: Ritchie, B.. University of Alberta; Canadá
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Fil: Smith, W. B.. Royal Adelaide Hospital. Clinical Immunology and Allergy; Australia
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Fil: Yang, W.. Allergy and Asthma Research Centre; Canadá
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Fil: Banerji, A.. Harvard Medical School; Estados Unidos
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Fil: Hébert, J.. Centre de Recherche Appliquée en Allergie de Québec; Canadá
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Fil: Gleich, G. J.. University of Utah; Estados Unidos
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Fil: Hurewitz, D.. Allergy Clinic of Tulsa; Estados Unidos
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Fil: Jacobson, K. W.. Allergy and Asthma Research Group; Estados Unidos
dc.description.fil
Fil: Bernstein, J. A.. University of Cincinnati; Estados Unidos
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Fil: Khan, D. A.. University of Texas. Southwestern Medical Center; Estados Unidos
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Fil: Kirkpatrick, C. H.. University of Colorado. Health Science Center; Estados Unidos
dc.description.fil
Fil: Resnick, D.. Columbia University; Estados Unidos
dc.description.fil
Fil: Li, H.. Shire; Estados Unidos
dc.description.fil
Fil: Fernández Romero, D. S.. Hospital Británico de Buenos Aires; Argentina
dc.description.fil
Fil: Lum, W.. AARA Research Centre; Estados Unidos
dc.journal.title
Clinical and Experimental Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/cei.12358
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/cei.12358/abstract
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