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dc.contributor.author
Gagliardino, Juan Jose
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Flores, Luis Emilio
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Alzugaray, Maria Eugenia
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Cubilla, Marisa Angelica
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Raschia, Maria A.
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del Zotto, Hector Herminio
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Román, Carolina Lisi
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Suburo, Angela Maria
dc.date.available
2016-01-07T16:50:52Z
dc.date.issued
2013-10
dc.identifier.citation
Gagliardino, Juan Jose; Flores, Luis Emilio; Alzugaray, Maria Eugenia; Cubilla, Marisa Angelica; Raschia, Maria A.; et al.; Islet Cannabinoid Receptors Cellular Distribution and Biological Function; Lippincott, Williams; Pancreas; 42; 10-2013; 1085-1092
dc.identifier.issn
0885-3177
dc.identifier.uri
http://hdl.handle.net/11336/3405
dc.description.abstract
Objectives: To determine the cellular distribution of islet cannabinoid receptors (CBs) and their involvement in the development of metabolic and hormonal changes in rats fed a fructose-rich diet (F). Methods: In normal rat islets, we determined CBs (immunofluorescence and RT-PCR) and glucose-stimulated insulin secretion (GSIS) of isolated islets incubated with the CB1 antagonist rimonabant (R) and/or different CBs agonists. In 3-week F-fed rats, we determined the in vivo effect of R upon serum glucose, triglyceride and insulin levels, HOMA-IR, GSIS and CBs and IRS gene expression levels (real-time PCR). Results: CBs appeared exclusively in islet α-cells. Whereas different CBs agonists enhanced GSIS in normal rat islets, R did not affect it. F rats had higher serum triglyceride and insulin levels and HOMA-IR than control rats; these alterations were prevented by R coadministration. Although R did not correct the increased GSIS observed in F islets, it modulated CBs and IRS gene expression. Conclusion: Islet CBs would exert an important modulatory role in metabolic homeostasis. Administration of R and F affected islet CBs expression and prevented the development of Finduced metabolic impairment. Selective islet CB1 blockers could be useful to prevent/treat the alterations induced by the intake of unbalanced/unhealthy diets.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott, Williams
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Cannabinoid Receptors,
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Pancreatic Islets,
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Metabolic Syndrome,
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A-Cell Function,
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Dyslipidemia,
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Metabolic Homeostasis
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Islet Cannabinoid Receptors Cellular Distribution and Biological Function
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
42
dc.journal.pagination
1085-1092
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Gagliardino, Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico La Plata; Argentina
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Fil: Flores, Luis Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico La Plata. Centro de Endocrinologia Experimental y Aplicada (i); Argentina
dc.description.fil
Fil: Alzugaray, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico la Plata; Argentina
dc.description.fil
Fil: Cubilla, Marisa Angelica. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
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Fil: Raschia, Maria A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico La Plata; Argentina
dc.description.fil
Fil: del Zotto, Hector Herminio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico La Plata; Argentina
dc.description.fil
Fil: Román, Carolina Lisi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico La Plata. Centro de Endocrinologia Experimental y Aplicada (i); Argentina
dc.description.fil
Fil: Suburo, Angela Maria. Universidad Austral. Facultad de Ciencias Biomedicas; Argentina
dc.journal.title
Pancreas
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/24005231
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